Ergelen, MineUsta Sağlam, Nazife GamzeArpacıoğlu, Mahmut SelimYalçın, Muratİzci, Filiz2025-08-142025-08-142025Ergelen, M., Sağlam, N. G. U., Arpacioğlu, M. S., Yalçin, M., & İzci, F. (2025). A Cross-sectional Analysis of Immunological and Hematological Parameters in Patients With Chronic Opioid Use. Journal of Psychiatric Practice®, 31(3), 116-124. 10.1097/PRA.00000000000008611527-41601538-1145https://hdl.handle.net/20.500.12939/5920Background and Aim: Previous research has recognized the dual role of opioids [agonists at μ-opioid receptors (MOP-r agonists)] in modulating immunity and neuroinflammation in individuals with opioid use disorder (OUD). This cross-sectional study investigates the interplay between chronic use of MOP-r agonists and inflammatory parameters in individuals with OUD, with the goal of providing insights into the relationship between immunological responses and OUD. Materials and Methods: A cohort of 129 patients with OUD seeking treatment at an addiction detoxification center underwent detailed clinical assessments. Blood samples were collected for analyses of serum alanine aminotransferase, aspartate aminotransferase, and C-reactive protein levels, and a complete blood count. Participants were categorized into inflammation and noninflammation groups based on C-reactive protein levels. Hematological and inflammation indices, along with pain severity, were compared between these groups. Results: Significant differences were observed between the inflammation and noninflammation groups on variables such as duration of MOP-r agonist intake, daily buprenorphine/naloxone dose, consumption route, severity of withdrawal symptoms, and level of self-reported pain. The inflammation group exhibited higher neutrophil counts and an increased neutrophil-to-lymphocyte ratio. The binary logistic regression models revealed that self-reported pain level, daily buprenorphine/naloxone dosage, Beck Depression Inventory scores, and age were significant predictors of inflammation. Conclusions: This study contributes to our understanding of OUD as a chronic inflammatory condition, shedding light on the intricate relationships between MOP-r agonist addiction, inflammatory responses, and withdrawal-related parameters. The findings offer valuable perspectives on effective management, emphasizing the need for further research in diverse populations to enhance understanding of this complex condition.eninfo:eu-repo/semantics/closedAccessC-reactive proteininflammationneutrophil-to-lymphocyte ratioopioid dependenceopioid use disorderArticle10.1097/PRA.0000000000000861313116124404406672-s2.0-105007048426Q3WOS:001498759900001Q4