Servi, HüseyinVatansever, CansuDoğan, AhmetMajeed, Vanya Ari2022-08-092022-08-092020Servi, H., Vatansever, C., Doğan, A., Majeed, V. A. (2020). Antibacterial activity and essential oil composition of Calendula arvensis L. International Journal of Secondary Metabolite, 7(4), 229-236.https://hdl.handle.net/20.500.12939/2835Essential oil composition and antibacterial activity of Calendula arvensis L. were investigated. The essential oil of aerial part was obtained through hydro-distillation using a Clevenger type apparatus with 0.38 (v/w) yield. The essential oil components were determined by GC-MS analyses. Thirty-six components were identified in the essential oil that represented 91.8 % of the oil. The major components of the essential oil were δ-cadinene (14.8 %), epi-cubebol (10.7 %), α-cadinol (8.5 %), cubenol (7.7 %), cubebol (7.2 %), 1-epi-cubenol (5.4 %) and ledene (5.1 %). Antibacterial activity of essential oil was observed against Staphylococcus aureus ATCC 29213, Bacillus cereus ATCC 14579, Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 by using a broth microdilution. The essential oil showed weak inhibitory activity against E. coli and B. cereus at 8 mg/mL. The oil didn‘t show any antibacterial activity against S. aureus and P. aeruginosa. These results revealed that the oil was rich in oxygenated sesquiterpenes as well as had a weak antimicrobial activity.eninfo:eu-repo/semantics/openAccessCalendula ArvensisEssential OilAntibacterial ActivityGC-MSArticle742292362-s2.0-85123163187Q3466215