Keskin, MutluLahteenmaki, HannaRathnayake, NilminieRaisanen, Ismo T.Tervahartiala, TainaParnanen, PirjoSorsa, Timo2021-05-152021-05-1520201478-94501744-8387https://doi.org/10.1080/14789450.2020.1858056https://hdl.handle.net/20.500.12939/121Raisanen, Ismo/0000-0001-5821-5299; Hagstrom, Jaana/0000-0001-6079-7881; Heikkila, Pia/0000-0002-5925-1993; Gursoy, Ulvi Kahraman/0000-0002-1225-5751Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. Research design and methods: Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Mouthrinse samples (pre-radiotherapy, after 6 weeks of radiotherapy and 1 month after radiotherapy) were assayed by aMMP-8 point-of-care-kit (PerioSafe (R)/ORALyzer (R)) for aMMP-8 and ELISA for IL-6. Results: HNC radiotherapy had a deteriorating impact on the periodontium and a significant impact on periodontal biomarkers aMMP-8 and IL-6 and increased their levels in mouthrinse. Clinical-attachment-loss (CAL) (site of greatest loss: mean = 1.7 mm, range = 1-3 mm) corresponding to rapid progression of periodontitis. There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. Conclusions: Elevated aMMP-8 levels were observed 1 month after radiotherapy among some HNC patients suggesting a prolonged increased susceptibility to further periodontal tissue destruction. Currently available aMMP-8 point-of-care testing could be useful to monitor and assess quantitatively online and real-time the risk of deterioration of periodontal health during HNC radiotherapy.eninfo:eu-repo/semantics/openAccessaMMP-8Head And Neck CancerIl-6PeriodontitisPoint Of Care TechnologyRadiotherapyReview Article10.1080/14789450.2020.18580561710777784334069242-s2.0-85099187563Q2WOS:000605385500001Q1