Özalp, V. CengizCam, DilekHernandez, Frank J.Hernandez, Luiza I.Schafer, ThomasÖktem, Hüseyin A.2021-05-152021-05-1520160003-26541364-5528https://doi.org/10.1039/c6an00273khttps://hdl.handle.net/20.500.12939/538Ozalp, Veli Cengiz/0000-0002-7659-5990; Hernandez, Frank J./0000-0001-6308-8087A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.eninfo:eu-repo/semantics/closedAccessMedicineSmall Molecule DetectionSilica NanoprobesArticle10.1039/c6an00273k141825952599270414742-s2.0-84964751474Q1WOS:000374037000038Q2