Yazar, MemetSevindik, MustafaUysal, ImranPolat, Abdullah Ozan2025-08-142025-08-142025Yazar, M., Sevindik, M., Uysal, I., & Polat, A. O. (2025). Effects of Caffeic Acid on Human Health: Pharmacological and Therapeutic Effects, Biological Activity and Toxicity. Pharmaceutical Chemistry Journal, 59(1), 49-55. 10.1007/s11094-025-03363-70091-150X1573-9031https://hdl.handle.net/20.500.12939/5921Phenolic compounds are bioactive compounds found in many natural products. Natural products exhibit biological activities because of their bioactive compounds. This review presents an overview of the general characteristics of caffeic acid, including its derivatives and biosynthesis, pharmacological and therapeutic effects, and biological activities. According to the literature research conducted, it has been reported that there are medical and pharmacological effects such as atherosclerotic, cardioprotective, immunomodulatory, hypertension, radiotherapy, neurodegeneration, neuroprotective, anxiety, vasoactive, dyslipidemia, and obesity. Furthermore, it has been observed that the substance possesses biological activities such as antioxidant, antihyperglycemic, antimicrobial, anticancer, cytotoxic, anti-inflammatory, anticoagulatory, antidiabetic, and antiviral properties. Within this scope, it is believed that caffeic acid could serve as a significant natural resource in pharmacological designs.eninfo:eu-repo/semantics/closedAccessbiological activitycaffeic acidpharmacologyphenolic compoundsArticle10.1007/s11094-025-03363-759149552-s2.0-105005546948Q4WOS:001491340900001Q4