Bağcı, GökhanÇıbık, SaraÖkten, Hatice2023-10-162023-10-162022Bağcı, G., Çıbık, S., Ökten, H. (2022). Brown/beige adipose tissue : novel players in the fight against obesity. AURUM Journal of Health Sciences, 4(3), 129-152.1234-5678https://hdl.handle.net/20.500.12939/4123Obesity is a metabolic disease which its prevalence is increasing worldwide. Multidisciplinary strategies are required to combat obesity. Many methods, from diet to surgery, are tried in obesity treatment. However, these methods have not been successful enough in the treatment of obesity. In recent years, a new adipose tissue type has been mentioned, with very important developments in adipose tissue biology. This type of adipose tissue is named as beige adipose tissue, different from white adipose tissue and classical brown adipose tissue. It has been observed that the beige adipocytes have a Brown-like characteristic and have thermogenesis abilities. It has been shown that beige adipocytes can develop in the white adipose tissue by a mechanism called browning, with the effect of various stimuli such as cold, hormones, exercise and dietary compounds. Brown/beige adipocytes are a candidate to be a new generation weight loss strategy and it is likely to have benefits against both obesity and its related metabolic diseases such as insulin resistance, diabetes, etc. To date, an increasing number of studies have been carried out to combat obesity by inducing browning of WAT by trying many compounds or methods, including cold exposure, various drugs, hormones, and plant-based agents. With the use of new generation nanotechnology-based therapies in the near future, specific molecules that can directly bind to brown/beige fat cells and activate the thermogenic program will be able to treat obesity. However, the therapeutic use of browning agents in people with obesity in the coming years will depend on the outcome of further randomised controlled trials.eninfo:eu-repo/semantics/openAccessObesityBrown adipose tissueBeige Adipose TissueBrowning of white adipose tissueArticle43129152