Keskin, Mutlu2021-06-112021-06-112020Keskin, M. (2020). A comparative analysis of biofilm characteristics of Dual-Species periodontopathogenic biofilm based on fusobacterium nucleatum and the Dual-Species biofilm response in the presence of antimicrobial peptide. Aurum Journal of Health Sciences, 2(1), 1-10.2651-2815https://hdl.handle.net/20.500.12939/2055Fusobacterium nucleatum (F.nucleatum), which acts as a linking periodontopathogenic bacteria, has the ability of coaggregation with early and late colonization species. It is the most intense gram-negative bacteria found in periodontal health and increases in periodontal diseased areas numerically. In this study, comparative analyses of dual and mono-biofilm structural characteristics formed by Porphyromonas gingivalis and Prevotella intermedia with F. nucleatum have been evaluated. In all results, more biofilm formation was observed in dual-species compared to monospecies biofilms. Biofilm formation of F. nucleatum-P.intermedia has increased in the presence of Human Neutrophilic Peptide (HNP-1). In this study it is concluded that dual-periodontopathogenic coaggregations based on F. nucleatum could produce more intense biofilm structure than single-species ones, and the increase in dual-species biofilm mass in the presence of low doses of HNP-1 may be a defense mechanism of dual periodontopathogenic biofilm.eninfo:eu-repo/semantics/openAccessPeriodontitisSubgingivalBiofilmAntimicrobialPeptideArticle21110