aMMP-8 oral Fluid PoC test in relation to oral and systemic diseases

Sorsa, TimoNwhator, Solomon OlusegunSakellari, DimitraGrigoriadis, AndreasUmeizudike, Kehinde AdesolaBrandt, EllaKeskin, MutluTervahartiala, TainaParnanen, PirjoGupta, ShipraMohindra, RitinBostancı, NagihanBuduneli, NurcanRaisanen, Ismo Tapani2022-07-052022-07-052022Sorsa, T., Nwhator, S. O., Sakellari, D., Grigoriadis, A., Umeizudike, K. A., Brandt, E., Keskin, M., Tervahartiala, T., Parnanen, P., Gupta, S., Mohidra, R., Bostancı, N., Buduneli, N., Räisänen, I. T. (2022). aMMP-8 oral fluid PoC test in relation to oral and systemic diseases. Frontiers in Oral Health, 3.https://hdl.handle.net/20.500.12939/2620The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.eninfo:eu-repo/semantics/openAccessAmmp-8Point-Of-Care (Poc)BiomarkerPeriodontitisPeri-ImplantitisSystemic DiseasesaMMP-8 oral Fluid PoC test in relation to oral and systemic diseasesArticle32-s2.0-85147181024N/AWOS:000995166500001N/A