Browsing by Author "Özalp, Veli Cengiz"
Now showing items 1-20 of 27
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Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Kavruk, Murat; Çelikbıçak, Ömer; Özalp, Veli Cengiz; Borsa, Barış Ata; Hernandez, Frank J.; Bayramoğlu, Gülay; Arıca, Yakup (Royal Soc Chemistry, 2015)In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease ... -
Aptamer-gated silica nanoparticles synthesized via click chemistry
Dilek, Özlem; Özalp, Veli Cengiz (Amer Soc Cell Biology, 2014)[No abstract available] -
Aptamers in medical diagnosis
Özalp, Veli Cengiz; Kavruk, Murat; Dilek, Özlem; Bayraç, Abdullah Tahir (Pan Stanford Publishing Pte. Ltd., 2016)Aptamers have been increasingly applied in biomedical field as a class of biorecognition elements that possess many advantages such as high specificity and binding affinity, easy synthesis, easy modification, small size, ... -
Aptamers: Molecular tools for medical diagnosis
Özalp, Veli Cengiz; Kavruk, Murat; Dilek, Özlem; Bayraç, Abdullah Tahir (Bentham Science Publ Ltd, 2015)Aptamers have been increasingly applied in biomedical field as a class of biorecognition elements that possess many advantages such as high specificity and binding affinity, easy synthesis, easy modification, small size, ... -
Comparison of a novel test (ODAK brucella coombs gel test) with commonly used serological tests in human brucellosis
Borsa, Barış Ata; Aldağ, Mehmet Ersoy; Yılmaz, Meriç; Dalar, Zeynep Güngördü; Özalp, Veli Cengiz (Clin Lab Publ, 2016)Background: Since Brucellosis is difficult to diagnose based on clinical symptoms, the diagnosis mostly relies on the results of serological testing. ODAK Brucella Coombs Gel Test is a novel and rapid gel microcolumn ... -
DNA Aptamers are functional molecular recognition sensors in protic Ionic liquids
Machado, Isabel; Özalp, Veli Cengiz; Rezabal, Elixabete; Schaefer, Thomas (Wiley-V C H Verlag Gmbh, 2014)The function and structural changes of an AMP molecular aptamer beacon and its molecular recognition capacity for its target, adenosine monophosphate (AMP), was systematically explored in solution with a protic ionic liquid, ... -
DNA-aptamer gating membranes
Schaefer, Thomas; Özalp, Veli Cengiz (Royal Soc Chemistry, 2015)This report describes a membrane barrier whose permeability is modulated through the recognition of a small-molecule target, adenosine triphosphate (ATP), by a DNA-aptamer. The gating function of the DNA-aptamer in the ... -
Examination of fabrication conditions of acrylate-based hydrogel formulations for doxorubicin release and efficacy test for hepatocellular carcinoma cell
Bayramoğlu, Gülay; Gözen, Damla; Ersoy, Gözde; Özalp, Veli Cengiz; Akçalı, K. Can; Arıca, M. Yakup (Taylor & Francis Ltd, 2014)The objective of the present study was to develop 2-hydroxypropyl methacrylate-co-polyethylene methacrylate [p(HPMA-co-PEG-MEMA)] hydrogels that are able to efficiently entrap doxorubicin for the application of loco-regional ... -
Fibrous polymer grafted magnetic chitosan beads with strong poly(cation-exchange) groups for single step purification of lysozyme
Bayramoğlu, Gülay; Tekinay, Turgay; Özalp, Veli Cengiz; Arıca, M. Yakup (Elsevier Science Bv, 2015)Lysozyme is an important polypetide used in medical and food applications. We report a novel magnetic strong cation exchange beads for efficient purification of lysozyme from chicken egg white. Magnetic chitosan (MCHT) ... -
Immobilized lipase on micro-porous biosilica for enzymatic transesterification of algal oil
Bayramoğlu, Gülay; Akbulut, Aydın; Özalp, Veli Cengiz; Arıca, M. Yakup (Inst Chemical Engineers, 2015)Enzymatic transesterification reactions for biodiesel production require harsh conditions, which require methods of enzyme stability enhancements. In this study, we present covalently immobilized lipase on the biosilica-polymer ... -
Improvement stability and performance of invertase via immobilization on to silanized and polymer brush grafted magnetic nanoparticles
Bayramoğlu, Gülay; Doz, Tuğce; Özalp, Veli Cengiz; Arıca, M. Yakup (Elsevier Sci Ltd, 2017)In this study, magnetic nanoparticles (Fe3O4) were modified sequentially with silica (Fe3O4@SiO2), glycidyl methacrylate (GMA) by surface initiated atom transfer radical polymerization (SI-ATRP) and hexamethylene diamine ... -
In situ monitoring of DNA-aptavalve gating function on mesoporous silica nanoparticles
Özalp, Veli Cengiz; Pinto, Alessandro; Nikulina, Elizaveta; Chuvilin, Andrey; Schaefer, Thomas (Wiley-V C H Verlag Gmbh, 2014)Mesoporous silica nanoparticles have proved to be efficient stimuli-responsive controlled release systems for drug delivery when functionalized with nanovalves. Nucleic acid aptamers have recently been adapted to function ... -
Inhibitory effects of aptamer targeted teicoplanin encapsulated PLGA nanoparticles for Staphylococcus aureus strains
Uçak, Samet; Sudağıdan, Mert; Borsa, Barış Ata; Mansuroğlu, Banu; Özalp, Veli Cengiz (Springer, 2020)Emergence of resistance to traditional antibiotic treatments necessitates alternative delivery systems. Teicoplanin is a glycopeptide antibiotic used in the treatments of serious infections caused by Gram-positive bacteria, ... -
Investigation of isepamicin, chloramphenicol and minocycline sensitivity in carbapenem-resistant enterobacteriaceae
Karakullukçu, Asiye; Borsa, Barış Ata; Kuşkucu, Mert Ahmet; Bakır, Esra; Taner, Zeynep; Özalp, Veli Cengiz; Aygun, Gökhan (Aves, 2018)Objective: In this study, we aimed to determine the resistance mechanisms of carbapenem-resistant Enterobacteriaceae (CRE), and evaluate the prospective alternative treatment options. Methods: Between October 2014 and July ... -
Karbapeneme dirençli enterik bakterilerde isepamisin, kloramfenikol ve minosiklin duyarlılığının araştırılması
Karakullukçu, Asiye; Borsa, Barış Ata; Kuşkucu, Mert Ahmet; Bakır, Esra; Taner, Zeynep; Özalp, Veli Cengiz; Aygün, Gökhan (2018)Amaç: Bu çalışmada, karbapeneme dirençli enterik bakteri (KDE)’lerin direnç özelliklerinin belirlenmesi ve ileriye yönelik alternatif tedavi seçeneklerinin değerlendirilmesi amaçlanmıştır. Yöntemler: Ekim 2014-Temmuz 2015 ... -
Kerstersia gyiorum: An unusual pathogen causing chronic suppurative otitis media
Borsa, Barış Ata; Kaplan, Hasan Hayri; Bayri-Barış, Ayşe; Güngördü-Dalar, Zeynep; Özalp, Veli Cengiz (Aves, 2017)Chronic suppurative otitis media was diagnosed in a 30-year old female with left ear pain and ear discharge lasting since 5 years intermittently. Lactose-negative, oxidase-negative, Gram-negative small bacilli grown as ... -
Label-free lateral flow assay for Listeria monocytogenes by aptamer-gated release of signal molecules
Taşbaşı, B. Büşra; Güner, Buket C.; Sudağıdan, Mert; Uçak, Samet; Kavruk, Murat; Özalp, Veli Cengiz (Academic Press Inc Elsevier Science, 2019)Lateral flow assay (LFA) type of biosensors have been popular due to cost-effectiveness and easy-interpretation for instant results, most common examples of applications being pregnancy tests, food safety or medical ... -
Magnetic polymeric beads functionalized with different mixed-mode ligands for reversible immobilization of trypsin
Bayramoğlu, Gülay; Özalp, Veli Cengiz; Arica, M. Yakup (Amer Chemical Soc, 2014)In this study, we describe a preparation of magnetic affinity support carrying different ligands for immobilization of trypsin via adsorption. The magnetic support was synthesized in the bead form using glycidylmethacrylate ... -
Nadir görülen fırsatçı patojen bacillus pumilus'un neden olduğu bir sepsis olgusu
Borsa, Barış Ata; Aldağ, Mehmet Ersoy; Tunalı, Birsen; Dinç, Uğur; Dalar, Zeynep Güngördü; Özalp, Veli Cengiz (2016)Bacillus türlerinin doğada yaygın olarak bulunması ve kültürlerde sıklıkla kontaminant olarak görülebilmesi, bu türlerin etken olup olmadığı konusunda tereddüt yaratmakla beraber, özellikle risk faktörlerine sahip bireylerde ... -
Nanocapsules in biomedicine promises and challenges
Hernandez, Frank J.; Kavruk, Murat; Hernandez, Luiza I.; Özalp, Veli Cengiz (Scrivener Publishing Llc, 2015)With the recent advances in nanotechnology, in the past decade, the ways of doing biomedicine have been reshaped considerably. Nanometer-size structures (nanoparticles, nanowires, nanocapsules, etc.) are used in biosensing, ...
