Browsing by Author "Hernandez, Frank J."
Now showing items 1-6 of 6
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Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Kavruk, Murat; Çelikbıçak, Ömer; Özalp, Veli Cengiz; Borsa, Barış Ata; Hernandez, Frank J.; Bayramoğlu, Gülay; Arıca, Yakup (Royal Soc Chemistry, 2015)In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease ... -
Nanocapsules in biomedicine promises and challenges
Hernandez, Frank J.; Kavruk, Murat; Hernandez, Luiza I.; Özalp, Veli Cengiz (Scrivener Publishing Llc, 2015)With the recent advances in nanotechnology, in the past decade, the ways of doing biomedicine have been reshaped considerably. Nanometer-size structures (nanoparticles, nanowires, nanocapsules, etc.) are used in biosensing, ... -
NanoKeepers: Stimuli responsive nanocapsules for programmed specific targeting and drug delivery
Hernandez, Frank J.; Hernandez, Luiza I.; Kavruk, Murat; Arıca, Yakup M.; Bayramoğlu, Gülay; Borsa, Barış Ata; Özalp, Veli Cengiz (Royal Soc Chemistry, 2014)Bacterial resistance is a high priority clinical issue worldwide. Thus, an effective system that rapidly provides specific treatment for bacterial infections using controlled dose release remains an unmet clinical need. ... -
Nuclease activity as a specific biomarker for breast cancer
Hernandez, Luiza I.; Cengiz Özalp, Veli; Hernandez, Frank J. (Royal Soc Chemistry, 2016)We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on ... -
Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes
Özalp, V. Cengiz; Cam, Dilek; Hernandez, Frank J.; Hernandez, Luiza I.; Schafer, Thomas; Öktem, Hüseyin A. (Royal Soc Chemistry, 2016)A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, ... -
Staphylococcus aureus detection in blood samples by silica nanoparticle-oligonucleotides conjugates
Borsa, Barış Ata; Tuna, Bilge G.; Hernandez, Frank J.; Hernandez, Luiza I.; Bayramoğlu, Gülay; Arıca, M. Yakup; Özalp, Veli Cengiz (Elsevier Advanced Technology, 2016)A fast, specific and sensitive homogeneous assay for Staphylococcus aureus detection was developed by measuring the activity of secreted nuclease from the bacteria via a modified DNA oligonucleotide. As biosensor format, ...