Browsing by Author "Keskin, Mutlu"
Now showing items 1-13 of 13
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Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: A pilot study
Keskin, Mutlu; Lahteenmaki, Hanna; Rathnayake, Nilminie; Raisanen, Ismo T.; Tervahartiala, Taina; Parnanen, Pirjo; Sorsa, Timo (Taylor & Francis Ltd, 2020)Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck ... -
aMMP-8 oral Fluid PoC test in relation to oral and systemic diseases
Sorsa, Timo; Nwhator, Solomon Olusegun; Sakellari, Dimitra; Grigoriadis, Andreas; Umeizudike, Kehinde Adesola; Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Parnanen, Pirjo; Gupta, Shipra; Mohindra, Ritin; Bostancı, Nagihan; Buduneli, Nurcan; Raisanen, Ismo Tapani (2022)The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic ... -
Author Response: Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study
Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Yılmaz, Mustafa; Harmankaya, İlknur; Karaçetin, Didem; İpek, Turgut; Gürsoy, Ulvi Kahraman; Rautava, Jaana; Gupta, Shipra; Hagström, Jaana; Raisanen, Ismo T.; Sorsa, Timo (2023)... -
A comparative analysis of biofilm characteristics of Dual-Species periodontopathogenic biofilm based on fusobacterium nucleatum and the Dual-Species biofilm response in the presence of antimicrobial peptide
Keskin, Mutlu (Altınbaş Üniversitesi, 2020)Fusobacterium nucleatum (F.nucleatum), which acts as a linking periodontopathogenic bacteria, has the ability of coaggregation with early and late colonization species. It is the most intense gram-negative bacteria found ... -
A comparative analysis of treatment-related changes in the diagnostic biomarker active metalloproteinase-8 levels in patients with periodontitis
Keskin, Mutlu; Rintamarttunen, Juulia; Gülçiçek, Emre; Räisänen, Ismo T.; Gupta, Shipra; Tervahartiala, Taina; Pätilä, Tommi; Sorsa, Timo (2023)Background: Previous studies have revealed the potential diagnostic utility of aMMP-8, an active form of MMP-8, in periodontal and peri-implant diseases. While non-invasive point-of-care (PoC) chairside aMMP-8 tests have ... -
Human β-defensins in diagnosis of head and neck cancers
Head and neck cancers are malignant growths with high death rates, which makes the early diagnosis of the affected patients of utmost importance. Over 90% of oral cavity cancers come from squamous cells, and the tongue, ... -
Induction of collagenolytic MMP-8 and -9 tissue destruction cascade in mouth by head and neck cancer radiotherapy: a cohort study
Brandt, Ella; Keskin, Mutlu; Raisanen, Ismo; Tervahartiala, Taina; Makitie, Antti; Harmankaya, İlknur; Karaçetin, Didem; Hagström, Jaana; Rautava, Jaana; Sorsa, Timo (2023)The effect of head and neck cancer (HNC) radiotherapy (RT) on biomarkers is not known but there is a lot of potential for gaining more precise cancer treatments and less side effects. This cohort study investigated the ... -
Oral cavity beta-defensin levels are regulated differently during radiotherapy in head and neck cancer patients
Keskin, Mutlu; Suomi, Emma; Harmankaya, İlknur; Karaçetin, Didem; Sorsa, Timo; Gürsoy, Ulvi Kahraman (MDPI, 2023)Background: Human beta-defensins (hBDs) are small cationic peptides of the epithelium with broad antimicrobial and immune response-regulatory activities. hBDs are also related to oncogenesis, and their secretion profiles ... -
Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy
Keskin, Mutlu; Kompuinen, Jenna; Harmankaya, İlknur; Karaçetin, Didem; Nissilä, Verneri; Gürsoy, Mervi; Sorsa, Timo; Gürsoy, Ulvi Kahraman (2022)Background: Lactoferrin, an iron-binding glycoprotein, and calprotectin, a calcium binding protein, are sensitive markers of inflammation and their fecal levels increase during radiotherapy of prostate cancer patients. ... -
Radiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study
Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Yılmaz, Mustafa; Harmankaya, İlknur; Karaçetin, Didem; İpek, Turgut; Gürsoy, Ulvi Kahraman; Rautava, Jaana; Gupta, Shipra; Hagström, Jaana; Raisanen, Ismo T.; Sorsa, Timo (2023)Radiotherapy for head and neck carcinoma (HNC) has both curative and palliative purposes. This study investigated mouthrinse aMMP-8 levels, molecular forms of MMP-8, blood neutrophil counts and neurophil/lymphocyte ratios ... -
Two cheers for Crohn's disease and periodontitis: Beta-defensin-2 as an actionable target to intervene on two clinically distinct diseases
Keskin, Mutlu; Zeidan-Chulia, Fares; Gürsoy, Mervi; Kononen, Eija; Rautava, Jaana; Gürsoy, Ulvi Kahraman (Mary Ann Liebert, Inc, 2015)Recent advances in multi-omics approaches encompassing genomics, transcriptomics, proteomics, and metabolomics offer hitherto unprecedented insights on common complex human diseases. A unique angle pertinent for both ...
