Browsing by Author "Sorsa, Timo"
Now showing items 1-9 of 9
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Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: A pilot study
Keskin, Mutlu; Lahteenmaki, Hanna; Rathnayake, Nilminie; Raisanen, Ismo T.; Tervahartiala, Taina; Parnanen, Pirjo; Sorsa, Timo (Taylor & Francis Ltd, 2020)Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck ... -
aMMP-8 oral Fluid PoC test in relation to oral and systemic diseases
Sorsa, Timo; Nwhator, Solomon Olusegun; Sakellari, Dimitra; Grigoriadis, Andreas; Umeizudike, Kehinde Adesola; Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Parnanen, Pirjo; Gupta, Shipra; Mohindra, Ritin; Bostancı, Nagihan; Buduneli, Nurcan; Raisanen, Ismo Tapani (2022)The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic ... -
Author Response: Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study
Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Yılmaz, Mustafa; Harmankaya, İlknur; Karaçetin, Didem; İpek, Turgut; Gürsoy, Ulvi Kahraman; Rautava, Jaana; Gupta, Shipra; Hagström, Jaana; Raisanen, Ismo T.; Sorsa, Timo (2023)... -
A comparative analysis of treatment-related changes in the diagnostic biomarker active metalloproteinase-8 levels in patients with periodontitis
Keskin, Mutlu; Rintamarttunen, Juulia; Gülçiçek, Emre; Räisänen, Ismo T.; Gupta, Shipra; Tervahartiala, Taina; Pätilä, Tommi; Sorsa, Timo (2023)Background: Previous studies have revealed the potential diagnostic utility of aMMP-8, an active form of MMP-8, in periodontal and peri-implant diseases. While non-invasive point-of-care (PoC) chairside aMMP-8 tests have ... -
Induction of collagenolytic MMP-8 and -9 tissue destruction cascade in mouth by head and neck cancer radiotherapy: a cohort study
Brandt, Ella; Keskin, Mutlu; Raisanen, Ismo; Tervahartiala, Taina; Makitie, Antti; Harmankaya, İlknur; Karaçetin, Didem; Hagström, Jaana; Rautava, Jaana; Sorsa, Timo (2023)The effect of head and neck cancer (HNC) radiotherapy (RT) on biomarkers is not known but there is a lot of potential for gaining more precise cancer treatments and less side effects. This cohort study investigated the ... -
Oral cavity beta-defensin levels are regulated differently during radiotherapy in head and neck cancer patients
Keskin, Mutlu; Suomi, Emma; Harmankaya, İlknur; Karaçetin, Didem; Sorsa, Timo; Gürsoy, Ulvi Kahraman (MDPI, 2023)Background: Human beta-defensins (hBDs) are small cationic peptides of the epithelium with broad antimicrobial and immune response-regulatory activities. hBDs are also related to oncogenesis, and their secretion profiles ... -
Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy
Keskin, Mutlu; Kompuinen, Jenna; Harmankaya, İlknur; Karaçetin, Didem; Nissilä, Verneri; Gürsoy, Mervi; Sorsa, Timo; Gürsoy, Ulvi Kahraman (2022)Background: Lactoferrin, an iron-binding glycoprotein, and calprotectin, a calcium binding protein, are sensitive markers of inflammation and their fecal levels increase during radiotherapy of prostate cancer patients. ... -
Radiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study
Brandt, Ella; Keskin, Mutlu; Tervahartiala, Taina; Yılmaz, Mustafa; Harmankaya, İlknur; Karaçetin, Didem; İpek, Turgut; Gürsoy, Ulvi Kahraman; Rautava, Jaana; Gupta, Shipra; Hagström, Jaana; Raisanen, Ismo T.; Sorsa, Timo (2023)Radiotherapy for head and neck carcinoma (HNC) has both curative and palliative purposes. This study investigated mouthrinse aMMP-8 levels, molecular forms of MMP-8, blood neutrophil counts and neurophil/lymphocyte ratios ...
