WoS İndeksli Yayınlar Koleksiyonu by Institution Author "Hekmatshoar, Yalda"
Now showing items 1-9 of 9
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Downregulation of stearoyl-CoA desaturase 1 (SCD-1) promotes resistance to imatinib in chronic Myeloid Leukemia
Altınok Güneş, Buket; Hekmatshoar, Yalda; Özkan, Tülin; Bozkurt, Süreyya; Erdoğan Aydos, O. Sena; Büyükaşık, Yahya; Aladağ, Elifcan; Sunguroğlu, Asuman (2023)Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease resulting in the fusion of BCR and ABL genes and characterized by the presence of the reciprocal translocation t(9;22)(q34;q11). BCR-ABL, a ... -
Evidence for health-promoting properties of Lepidium Sativum L.: an updated comprehensive review
Lepidium sativum L. is a common herb distributed worldwide, used as a food ingredient and therapeutic agent in traditional medicine for treating health-related disorders. L. sativum and its extracts have been described to ... -
Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a bioinformatics study
Hekmatshoar, Yalda; Saadat, Yalda Rahbar; Özkan, Tülin; Bozkurt, Süreyya; Gürel, Aynur Karadağ (2023)Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors, which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment ... -
Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia
Karabay, Arzu Zeynep; Özkan, Tülin; Gürel, Aynur Karadağ; Koç, Aslı; Hekmatshoar, Yalda; Sunguroğlu, Asuman; Aktan, Fügen; Büyükbingöl, Zeliha (2024)Chemotherapy resistance is a major obstacle in cancer therapy, and identifying novel druggable targets to reverse this phenomenon is essential. The exosome-mediated transmittance of drug resistance has been shown in various ... -
Methylsulfonylmethane induces caspase-dependent apoptosis in acute myeloid leukemia cell lines
Background: Acute myeloid leukemia (AML) is a heterogeneous ailment in both biological and clinical concepts. Numerous efforts have been devoted to discover natural compounds for combating cancer, which showed great potential ... -
Nilotinib exhibits less toxicity than imatinib and influences the immune state by modulating iNOS, p-p38 and p-JNK in LPS/IFN gamma-activated macrophages
Karabay, Arzu Zeynep; Özkan, Tülin; Koç, Aslı; Hekmatshoar, Yalda; Gürkan-Alp, A. Selen; Sunguroğlu, Asuman (2023)In this study, we aimed to analyze the effects of first and second-generation Bcr-Abl tyrosine kinase inhibitors, imatinib and nilotinib on LPS/IFN gamma activated RAW 264.7 macrophages. Our data revealed that imatinib was ... -
Phenotypic and functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line
Hekmatshoar, Yalda; Karadağ Gürel, Aynur; Özkan, Tülin; Saadat, Yalda Rahbar; Koç, Aslı; Karabay, Arzu Zeynep; Bozkurt, Süreyya; Sunguroğlu, Asuman (2023)Purpose: Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of BCR-ABL protein. Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets ... -
Some 2-[4-(1H-benzimidazol-1-yl) phenyl]-1H-benzimidazole derivatives overcome imatinib resistance by induction of apoptosis and reduction of P-glycoprotein activity
Imatinib (IMA) is a tyrosine kinase inhibitor (TKI) introduced for the chronic myeloid leukemia (CML) therapy. Emergence of IMA resistance leads to the relapse and failure in CML therapy. Benzimidazole is a heterocyclic ...
