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dc.contributor.authorBrandt, Ella
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorHarmankaya, İlknur
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorİpek, Turgut
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.contributor.authorRautava, Jaana
dc.contributor.authorGupta, Shipra
dc.contributor.authorHagström, Jaana
dc.contributor.authorRaisanen, Ismo T.
dc.contributor.authorSorsa, Timo
dc.identifier.citationBrandt, E., Keskin, M., Tervahartiala, T., Yılmaz, M., Harmankaya, İ., Karaçetin, D., ... & Sorsa, T. (2023). Radiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study. Cancer Control, 30.en_US
dc.description.abstractRadiotherapy for head and neck carcinoma (HNC) has both curative and palliative purposes. This study investigated mouthrinse aMMP-8 levels, molecular forms of MMP-8, blood neutrophil counts and neurophil/lymphocyte ratios before and 3 weeks after HNC radiotherapy started. Thirteen HNC patients undergoing radiotherapy were included. Mouthrinse samples (before and 3 weeks after HNC radiotherapy had started) were assayed quantitatively by aMMP-8 point-of-care-kit (PerioSafe®/ORALyzer®) and by western immunoblot. Total neutrophil counts and neutrophil/lymphocyte ratios were evaluated in the hemogram results. Three weeks after HNC radiotherapy started, significant increases in aMMP-8 levels and neutrophil/lymphocyte ratios were observed. No significant difference was found in total neutrophil counts. Elevations of the activated and fragmented MMP-8 levels after HNC radiotherapy application were observed on western immunoblot analysis. The increase in the aMMP-8 levels and neutrophil/lymphocyte ratios indicate inflammation both locally and systemically suggesting increased risk for periodontitis due to the HNC radiotherapy.en_US
dc.subjectaMMP -8en_US
dc.subjectHead And Neck Canceren_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectPoint Of Care Technologyen_US
dc.titleRadiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot studyen_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.contributor.institutionauthorKeskin, Mutlu
dc.contributor.institutionauthorİpek, Turgut
dc.relation.journalCancer control : journal of the Moffitt Cancer Centeren_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US

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