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    A novel marker for esophageal cancer: Senescence marker protein-30
    (2024) Kızıltan, Remzi; Aydın, Mehmet Akif; Algül, Şermin; Kemik, Özgür
    Aim: Esophageal cancer is one of the most common malignancies causing the majority of cancer -related deaths worldwide. The aim of this study was to examine the importance of preoperative Senescence marker protein -30 (SMP30) levels in patients with esophageal cancer. Material and Methods: Medical records of 85 patients who were diagnosed with esophageal cancer were reviewed and compared with those of the control subjects. The tumor marker was measured with Enzyme -linked immunosorbent assay (ELISA). Results: No statistically significant difference was found between the patient and study groups in terms of age and gender. In our study, we found that serum SMP30 levels were significantly lower in esophageal cancer patients than in healthy controls. Discussion: We found that the adhesion of esophageal cancer cells was significantly reflected by preoperative serum levels of the studied marker, indicating the adhesive strength of cancer cells. SMP30 may be a novel strategy for clinical diagnosis of the disease.
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    B7-H3 : A useful emerging diagnostic marker for colon cancer
    (2022) Bostancı, Özgür; Sayın, Pınar; Kızıltan, Remzi; Algül, Şermin; Aydın, Mehmet Akif; Kemik, Özgür
    Background: Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those that are replaced in colon cancer. Method: We measured preoperative serum B7-H3 concentrations of 90 patients aged 57-69 years diagnosed with colon cancer and 50 age-matched healthy individuals. B7-H3 levels were determined using the sandwich enzyme-linked immunosorbent assay (ELISA). Patients were categorized by stage based on the TNM staging system, and the serum levels of B7-H3 were compared between patients with different TNM stages. Result: No statistically significant difference was found between the patient and control groups in terms of age and gender. Preoperative serum B7-H3 levels were statistically significantly higher in patients with colon cancer than in the healthy group (p < 0.001). Preoperative serum B7-H3 concentration of the stage IV patients was significantly higher than those of the patients with stage I and stage II disease. In addition, higher serum B7-H3 levels were associated with lymph node status and distant metastasis in colon cancer. Conclusion: We showed that B7-H3 is highly expressed in colon cancer and can be used as a candidate diagnostic biomarker and a potential target in colon cancer in future.
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    Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility
    (2024) Gül, Güngör; Aydın, Mehmet Akif; Algül, Şermin; Kızıltan, Remzi; Kemik, Özgür
    Background: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients. Methods: A total of 85 patients [mean (SD) age: 60.9 (1.6) years, 49.4% were males] with newly-diagnosed gastric cancer and 40 healthy individuals [mean (SD) age: 60.7 (1.7) years, 52.5% were males] were included. Data on patient demographics (age, gender), TNM stages and tumor size, and the serum NAP1L1 levels were recorded. Results: Serum NAP1L1 levels were significantly higher in gastric cancer patients than in control subjects [12 (9.5-13.8) vs. 1.8 (1.5-2.4) ng/mL, p < 0.001]. Also, certain tumor characteristics such as tumor size of >4 vs. <4 cm (p < 0.001), M1 vs. M0 stage (p < 0.001), N2 vs. N0 and N1 stage (p < 0.001), and T4 vs. lower T stage (p < 0.001) were associated with significantly higher serum NAP1L1 levels in gastric cancer patients. Conclusions: Our findings revealed for the first time that serum levels for NAP1L1 were overexpressed in the gastric cancer, as also correlated with the disease progression. NAP1L1 seems to be a potential biomarker for gastric cancer, providing clinically important information on early diagnosis and risk stratification.