Altınbaş Üniversitesi Kurumsal Akademik Arşivi
DSpace@Altınbaş, Altınbaş Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Validity and reliability study of the Turkish version of the Addiction Severity Index
(Kare Publishing, 2025) Bilici, Rabia; Ergelen Yalçın, Mine; Karabulut, Sercan; Arpacıoğlu, Mahmut Selim; Salavran, Sevdenur; Yılmaz, Emre
Objective: The increasing prevalence of alcohol and substance use disorders (ASUD) worldwide has raised the demand for more efficient treatment and monitoring. Comprehensive assessment tools are crucial for evaluating substance use, as well as medical, legal, and psychosocial aspects to provide holistic care. The Addiction Severity Index (ASI) is a commonly used tool to assess these dimensions. The purpose of this research is to validate the ASI-Treatnet version in a sample from Turkiye. Method: The research was carried out at AMATEM clinics in Istanbul and Antalya, involving 141 patients who had been diagnosed with ASUD based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. The ASI was translated into Turkish, and its reliability and validity were assessed through a methodology that included testing for test-retest and interrater reliability using Spearman-Brown correlation coefficients. Results: The results indicated high reliability for all subscales. Internal consistency was assessed through Cronbach’s alpha, resulting in an acceptable value of 0.82. Concurrent validity was established by examining the correlations with the Michigan Alcoholism Screening Test, the Drug Abuse Screening Test, and the Beck Depression Inventory, all of which demonstrated significant correlations with the ASI subscales. Conclusion: The study revealed that the Turkish adaptation of the ASI is a reliable and valid instrument for evaluating ASUD. Its strong correlations with established screening tools confirm its concurrent validity. The ASI’s multidimensional approach allows for a comprehensive assessment, facilitating individualized treatment planning and monitoring. Future research could explore expanded and online-adapted versions of the ASI to enhance its practicality.
Comparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications
(Wiley-Liss, 2025) Aslan, Muzaffer; Okşen, Doğaç; Yavuz, Yunus Emre; Kaynak, Çağdaş
Background: Percutaneous coronary intervention (PCI) has evolved with the development of drug-eluting stents (DES) and drug-coated balloons (DCB), both of which play a crucial role in reducing restenosis and major adverse cardiovascular events (MACE). Despite their benefits, the oxidative stress response triggered by these interventions and its implications for vascular healing remain unclear. Aims: This study aims to compare the oxidative stress burden associated with DES and DCB by evaluating changes in plasma total peroxidase (TP) levels over time. Methods: This observational, comparative study included 110 patients (60 DES and 50 DCB) who underwent PCI for stable coronary artery disease. TP levels were measured pre-procedure, 24 h postprocedure, and 1 month after PCI. Statistical comparisons were used to determine significant differences in oxidative stress between the two groups over time. Results: Preoperative TP levels were comparable between the DES and DCB groups (431.00 ± 4.56 vs. 436.50 ± 4.14 µmol/L, p = 0.110). At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (p = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, p = 0.11). Conclusion: This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. These preliminary findings highlight the potential of DCBs to foster quicker vascular recovery, warranting further investigation into their long-term clinical advantages.
Improving machine learning detection of Alzheimer disease using enhanced manta ray gene selection of Alzheimer gene expression datasets
(PeerJ Inc., 2025) Ahmed, Zahraa; Çevik, Mesut
One of the most prominent neurodegenerative diseases globally is Alzheimer's disease (AD). The early diagnosis of AD is a challenging task due to complex pathophysiology caused by the presence and accumulation of neurofibrillary tangles and amyloid plaques. However, the late enriched understanding of the genetic underpinnings of AD has been made possible due to recent advancements in data mining analysis methods, machine learning, and microarray technologies. However, the "curse of dimensionality" caused by the high-dimensional microarray datasets impacts the accurate prediction of the disease due to issues of overfitting, bias, and high computational demands. To alleviate such an effect, this study proposes a gene selection approach based on the parameter-free and large-scale manta ray foraging optimization algorithm. Given the dimensional disparities and statistical relationship distributions of the six investigated datasets, in addition to four evaluated machine learning classifiers; the proposed Sign Random Mutation and Best Rank enhancements that substantially improved MRFO's exploration and exploitation contributed to efficient identification of relevant genes and to machine learning improved prediction accuracy.
Commentary on "The relationship between risky sexual behaviors and sexual health literacy and self-esteem in young women"
(Associação Médica Brasileira, 2025) Çetin, Buğra
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Feeding Challenges in Children With Down Syndrome: The Role of Aspiration and Clinical Subgroups
(Clevedon, 2025) Tanrıverdi, Müberra; Zengin Yazıcı, Gülşah; Yılmaz, Güleser Güney; Uygur Şahin, Türkan
Background: Feeding difficulties, including aspiration risk, are common in children with Down syndrome. Identifying factors affecting feeding modality is crucial. Method: This cross-sectional study included 335 children with Down syndrome (aged 4–12 years; mean 5.2). Feeding was assessed using the Functional Oral Intake Scale (FOIS), the Screening Tool of Feeding Problems (STEP), and clinical observation. Aspiration risk was identified through STEP items and clinician evaluation. FOIS scores categorised feeding as oral or non-oral. Results: Of participants, 74.1% were oral feeders and 25.9% received non-oral nutrition. Aspiration risk was present in 33.7%. Cluster analysis revealed distinct subgroups defined by aspiration, oral sensory issues, and behavioural problems. Younger age was significantly associated with higher aspiration risk (OR = 0.38, p = 0.001). Conclusions: Aspiration risk influences feeding modality and subgroup characteristics. Early multidisciplinary assessment is essential, especially for younger children, to detect risk and guide safe, individualised feeding strategies.
