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    Colonoscopy screening for colon polyps: Can it be useful at an earlier age for preventing malignant transformation?
    (Bayrakol Medical Publisher, 2021) Aydin, Muhammet Fatih; Aydin, Mehmet Akif
    Aim: The aim of this study was to investigate whether colonoscopy screening should be performed at an earlier age than specified in the current guidelines. Material and Methods: Data of 1882 patients who presented to the gastroenterology clinic of our hospital and underwent colonoscopy were retrospectively evaluated. Polyps detected during colonoscopy were excised and sent to the pathology laboratory for histopathological examination. Patients were divided into two groups as <45 years old and >= 45 years old, and the data were compared between the groups. Results: The most common indications for colonoscopy were abdominal pain in 40.6% of the patients, rectal bleeding in 18.6%, constipation in 14.2%, anemia in 10.5%, diarrhea in 3.1%, and other reasons in 6.8%. The rate of polyps was statistically significantly higher in patients aged >= 45 years (43.3%) compared to patients aged <45 years (32.1%). The rate of neoplastic polyps was statistically significantly higher in the group aged >= 45 years compared to the group aged <45 years. The most common localizations of polyps were rectum and sigmoid colon in all age groups. Discussion: Based on our findings, we believe that the onset age of screening for colon polyps should be 45 years, as recommended by the updated guidelines. Also, colonoscopy screening should be performed in young adults without alarm symptoms who present with lower gastrointestinal complaints.
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    Effects of serum biochemical parameters on the prevalence of colon polyps
    (Bayrakol Medical Publisher, 2021) Aydin, Muhammet Fatih
    Aim: Early detection of colorectal polyps is important to prevent malignant transformation. The levels of several metallic and hematologic parameters may be indicators of these polyps. The objective of this study was to investigate whether iron levels may indicate the presence of colorectal polyps. Material and Methods: A total of 897 patients who underwent routine biochemical analysis and colonoscopy were retrospectively evaluated. Patients were grouped as polyp (-) and polyp (+) and further divided into two groups as those with neoplastic polyps and the patients with non-neoplastic polyps. The levels of iron, ferritin, hemoglobin, glucose, cholesterol, triglycerides and vitamin D were compared between the groups. Results: Males accounted for 60.5% of all patients, and 39.5% were females. The mean age of the patients was found as 43.3 +/- 11.9 years. The mean iron (p=0.023), ferritin (p=0.002), cholesterol (p=0.008) and triglycerides (p=0.005) levels were significantly higher in patients with polyps compared to those without polyps. The mean iron (p=0.001), ferritin (p<0.001), hemoglobin (p<0.001) and triglyceride (p=0.007) levels were higher in the males compared to the females. The mean iron (p<0.001), ferritin (p<0.001) and cholesterol (p=0.020) levels were significantly higher in patients with neoplastic polyps compared to those with non-neoplastic polyps. Discussion: Iron levels were elevated in individuals with colorectal polyps and further elevated in patients with neoplastic polyps. Determination of cut-off values of iron and other parameters in predicting colorectal polyps will enable early detection of colorectal polyps and proper intervention.