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    Exploring free amino acid profiles in Crimean-Congo hemorrhagic fever patients: Implications for disease progression
    (Wiley, 2024) Buyuktuna, Seyit Ali; Yerlitas, Serra Ilayda; Zararsiz, Goezde Ertuk; Dogan, Kuebra; Kablan, Demet; Bagci, Gokhan; Ozer, Selda
    This study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus infection and alterations in amino acid metabolism. The primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease.
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    Vitamin D Receptor Polymorphisms in Overweight/Obese Chronic Kidney Disease Patients on Dialysis
    (AVES, 2024) Bagci, Gokhan; Huzmeli, Can; Bagci, Binnur; Candan, Ferhan
    Background: Little is known about the possible association of vitamin D receptor (VDR) gene polymorphisms in obese patients with chronic kidney disease on dialysis (CKD-G5D). Therefore, we aimed to investigate VDR gene TaqI, ApaI, and FokI single-nucleotide polymorphisms (SNPs) in overweight/obese CKD-G5D patients. Methods: Seventy-one normal-weight and 68 overweight/obese CKD-G5D patients were included in the study. The polymerase chain reaction-restriction fragment length polymorphism method was used for genotyping. Demographic and laboratory data were obtained from the medical records of patients. Results: For all 3 SNPs, no significant association was found between normal-weight and overweight/obese patients ( P > .05). High-density lipoprotein (HDL) concentrations were lower, but triglyceride (TG) and glucose levels were higher in overweight/obese patients compared to normal-weight patients ( P < .001 for HDL and TG and P = .023 for glucose). In overweight/obese patients, individuals with the TaqI CC genotype had higher (PTH) levels than those with TC and TT genotypes (CC = 717.1 +/- 616.4, TC = 342.7 +/- 360.8, and TT = 310.2 +/- 323.4 pg/mL; P = .028). Similarly, patients with the ApaI genotype (627.3 +/- 653.0 mg/dL) had higher TG levels than those with the AA and AC genotypes (CC = 627.3 +/- 653.0, AA = 223.3 +/- 156.6, AC = 193.1 +/- 85.4; P < .001). Overweight/obese patients with the FokI TT genotype had higher glucose concentrations than those with the CC and CT genotypes (CC = 183.4 +/- 128.4 mg/dL, TT = 151.9 +/- 66.1 mg/dL, and CT = 107.6 +/- 41.9 mg/dL; P = .008). Conclusion: Our study suggests that VDR TaqI, ApaI, and FokI polymorphisms are not associated with obesity in CKD-G5D patients. However, they might increase the risk of secondary hyperparathyroidism, dyslipidemia, and hyperglycemia.