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    Dentin-pulp tissue regeneration approaches in dentistry: An overview and current trends
    (Springer, 2020) Şişmanoglu, Soner; Ercal, P.
    Conventional treatment approaches in irreversible pulpitis and apical periodontitis include the disinfection of the pulp space followed by filling with various materials, which is commonly known as the root canal treatment. Disadvantages including the loss of tooth vitality and defense mechanism against carious lesions, susceptibility to fractures, discoloration and microleakage led to the development of regenerative therapies for the dentin pulp-complex. The goal of dentin-pulp tissue regeneration is to reestablish the physiological pulp function such as pulp sensibility, pulp repair capability by mineralization and pulp immunity. Recent dentin-pulp tissue regeneration approaches can be divided into cell homing and cell transplantation. Cell based approaches include a suitable scaffold for the delivery of potent stem cells with or without bioactive molecules into the root canal system while cell homing is based on the recruitment of host endogenous stem cells from the resident tissue including periapical region or dental pulp. This review discusses the recent treatment modalities in dentin-pulp tissue regeneration through tissue engineering and current challenges and trends in this field of research. © Springer Nature Switzerland AG 2020.
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    Öğe
    Third molar agenesis: Prevalence and association with agenesis of other teeth in a Turkish population
    (Wolters Kluwer Medknow Publications, 2020) Ercal, P.; Taysi, A. E.
    Background: Tooth agenesis is the congenital lack of one or more primary or permanent teeth and it is the most frequently seen dental anomaly. The prevalence of third molar agenesis is significantly higher than the agenesis of other teeth varying from 10% to 40% and shows geographical variance. Aims: The aim of this study was to investigate the prevalence of third molar agenesis and its association with other tooth agenesis of jaws. Subjects and Methods: A total of 594 Turkish subjects with or without agenesis of third molars (M3) were included in the study. Dental records and panoramic radiographs were evaluated for M3 agenesis, hypodontia and hyperdontia. Significant differences in the prevalence rate of M3 agenesis between genders among with evaluation of coexistence of M3 and other tooth agenesis were determined by Fisher's exact test. Results: The prevalence of M3 agenesis was determined as 28.7% with no statistically significant gender or location difference. Most common form of M3 agenesis involved one molar followed by two, four and three molars. Agenesis of other teeth was seen among both patient groups with and without M3 agenesis, without significant difference. Conclusions: Turkish population with M3 agenesis did not show increased prevalence of other tooth agenesis, indicating no association between occurrence of agenesis of other teeth and M3.