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Öğe Advanced hybrid and preprocessing models for diagnosis challenges in data classification(Engineering and Technology Publishing, 2024) Fayez, Mustafa Adil; Kurnaz, SeferMachine Learning (ML), often viewed as a cutting-edge technology best suited for qualified specialists, presents limited access for other physicians and scientists in the medical profession. In this work, we provide a new, sophisticated, and highly successful technology for medical applications, especially cardiac diagnostics. We propose a novel advanced hybrid optimization model with two essential parts. Initially, we apply a high-performance hybrid resampling technique for feature engineering and pre-processing. This approach, which combines Synthetic Minority Oversampling Technique Edited Nearest Neighbors (SMOTEENN) with Neighborhood Cleaning Rules (NCL), addresses class imbalance in the data. We developed a complex hybrid optimization model that incorporates hyper-parameter optimization, advanced Application Programming Interface (API) functions, and a super-learner ensemble model to enhance diagnosis accuracy in cases where datasets lack balance. Furthermore, we developed high-performance prediction models using sophisticated Support Vector Machines (SVMs). We show that, with re-sampled Cardiovascular Disease (CVD) data, the advanced hybrid optimization model attained an astounding accuracy of 98%. By comparison, an advanced SVM model obtained 96% accuracy, while an advanced deep learning model produced 95.5% accuracy. Our new sophisticated hybrid optimization machine learning models may significantly improve physicians’ interpretation of ML results. This strategy could make it easier to apply AI methods on a large scale in the clinic, which would eventually raise patient outcomes and diagnostic accuracy.