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    Öğe
    The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ
    (Sociedade Brasileira De Pesquisa Odontologica, 2019) Taysi, Aysegul Erten; Cevher, Erdal; Sessevmez, Melike; Olgac, Vakur; Taysi, Nuri Mert; Atalay, Berkem
    Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient's symptoms under control. In this study, we aimed to investigate a new treatment protocol for medication-related osteonecrosis of the jaw (MRONJ). This treatment protocol consisted of administering human parathyroid hormone (hPTH) loaded chitosan microspheres which were prepared by ionotropic gelation method or/and the prepared microspheres were suspended in a poloxamer gel. After in-vitro optimization studies, the efficacy of the chosen formulations was evaluated in-vivo studies. Zoledronic acid was administered daily to forty-eight adult female Sprague-Dawley rats, divided into four experimental groups, at a daily concentration of 0.11 mg/kg over three weeks to induce the MRONJ model. At the end of this period, maxillary left molar teeth were extracted. In the first group, the subjects received no treatment. In the negative control group, poloxamer hydrogel containing empty microspheres were immediately applied to the soft tissues surrounding the extraction socket. The treatment group-1 was treated with local injections of poloxamer hydrogel containing hPTH. The treatment group-2 was treated with a single local injection of poloxamer hydrogel containing hPTH-loaded chitosan microspheres. Both treatment groups received a total of 7 mu g of hPTH at the end of the treatment protocol. Our study demonstrates successful attenuation of MRONJ through a local drug delivery system combined with hPTH, as opposed to previously attempted treatment strategies.
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    Öğe
    Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study
    (2022) Aksoy, Nilay; Sen, Emine; Sukmasari, Susi; Özakpınar, Özlem Bingöl; Arıcıoğlu, Feyze; Yücel, Yasemin Yücel; Dumlu, Muhammet Rıdvan; Doolaanea, Abd Almonem; AbdulRahman, Mohammad Nasrin; Olgac, Vakur; Bozkan, Pırıl; Ozen, Bugra
    Purpose The study aimed to evaluate the possible preventive efect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the ffth day of the study, the cheek and sublingual mucosa were irritated by external superfcial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-infammatory markers and biochemical tests were analyzed. Signifcant diferences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-infammatory parameters. Conclusion The preventive efect of 3% gel was signifcant, with no mortality rate, making it an option for preventive strategies..