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    Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing
    (2024) Orhan, Burcu; Karadeniz, Duygu; Kalaycıoğlu, Zeynep; Kaygusuz, Hakan; Torlak, Emrah; Erim, F. Bedia
    Foam-based wound dressing materials produced by dispersing gas phases in a polymeric material are soft, adapt to the body shape, and allow the absorption of wound exudate due to their porous structure. Most of these formulations are based on synthetic substances such as polyurethane. However, biopolymers have entered the field as a new player thanks to their biocompatible and sustainable nature. Incorporating biopolymers in formulations is gaining interest in scientific literature, and we extend this approach by adding antibacterial cerium oxide nanoparticles to biopolymer formulation. We introduce a novel biopolymer composite of carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and cerium oxide nanoparticles (CeO2 NPs), namely PVA-CMC@CeO2. This mixture was first foamed and then cross-linked with sodium tetraborate solution, followed by a freeze-thaw process. After the novel material's spectroscopic, structural, and morphological characterization, we investigated its swelling, drug-delivery, antibacterial, and biodegradability properties PVA-CMC@CeO2 dressing effectively inhibits Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) growth and delivers the antibiotic drug silver sulfadiazine for up to 6 h. The antibacterial properties, good swelling, and drug release profile of the blend material show promising potential in wound care applications.
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    Sustainable alginate-carboxymethyl cellulose superabsorbents prepared by a novel quasi-cryogelation method
    (Springer, 2022) Orhan, Burcu; Kaygusuz, Hakan; Erim, F. Bedia
    The research in biopolymer-based superabsorbents is gaining importance in the green chemistry feld thanks to their environmentally friendly properties. In this study, a biopolymer-based superabsorbent made of calcium ion crosslinked alginate/ carboxymethyl cellulose composite was prepared by a new quasi-cryogelation process, where the complete ionic gelation takes place before the freezing step, in contrast to the conventional cryogelation technique in which gelation occurs under semi-frozen conditions. Thanks to the facile quasi-cryogelation method, the morphology of the gels changed and a signifcant increase in water absorption properties has been achieved. The swelling properties of the material were investigated in distilled water and diferent physiological fuids. Results show that the proposed material shows good water absorption property where a water absorption of 2343% was reached and even after fve cycles this value was 1200%. As a result, this study reports a biopolymer-based sustainable superabsorbent which is appropriate for various applications such as the removal of pollutants from water or diaper production.