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    Effects of the pathological characteristics on the presence of multicentric thyroid tumors in the contralateral lobe
    (Bayrakol Medical Publisher, 2022) Pamukcu, Muhammet; Demir, Emine; Aydin, Mehmet Akif
    Aim: In this study, we aimed to investigate the effects of pathological tumor characteristics on the presence of a multicentric tumor in the contralateral lobe in papillary thyroid carcinoma (PTC). Material and Methods: A total of 46 patients aged over 18 years who underwent total thyroidectomy due to PTC in our clinic were retrospectively evaluated. Patients' demographic data such as age and gender, preoperative USG findings, postoperative pathological findings, lobe localization, and the presence of nodules in the contralateral lobe were recorded. In addition, tumor size, presence of nuclear atypia, mitotic activity, vascular invasion and extrathyroidal spread of the tumor and the presence of lymph node metastasis were obtained from pathological reports. Patients were divided into two groups as multicentric and non-multicentric, and the data were compared between these groups. Results: The mean age of the patients was 44.9 +/- 12.3 years. Twenty-three patients had papillary thyroid microcarcinoma and 23 patients had papillary thyroid carcinoma. Postoperative pathological examination revealed multicentric PTCs in 15 patients . No statistically significant difference was found between patients with and without multicentric contralateral lobe tumors in terms of primary tumor diameter, nuclear atypia, mitotic activity, tumor necrosis, vascular invasion, extrathyroidal spread and lymph node metastasis (for all p>0.05). Discussion: The pathology of the tumor in the contralateral lobe of the primary nodule can be seen with preoperative USG in the majority of patients with PTC. The presence of a multicentric tumor in the contralateral lobe is not correlated with tumor size and pathological characteristics of the tumor.
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    Investigation of the effectiveness of granulocyte colony-stimulating factor (G-CSF) in the treatment of atrophic rhinitis
    (Bayrakol Medical Publisher, 2022) Pamukcu, Muhammet; Ada, Mehmet; Ozbilen, Gul
    Aim: Primary acute rhinitis (AR) remains a clinical problem in developing countries. The objective of this study was to investigate the effectiveness of granulocyte colony-stimulating factor (G-CSF) administration as an alternative to current treatment methods. Material and Methods: Eighteen rabbits were divided into three groups with six rabbits in each. Group 1 consisted of the rabbits followed up without any treatment as healthy animal group. Pasteurella multocida solution was inoculated into the noses of 12 rabbits in Groups 2 and 3 with a micropipette in order to induce atrophic rhinitis. After three weeks of inoculation, rabbits in Group 1 and Group 2 were sacrificed. Group 3 was administered 5 microgram/kg G-CSF and sacrificed after four weeks. Total turbinate thickness, turbinate bone thickness, turbinate mucosal thickness, degree of cilia loss in epithelial cells, amount of submucosal gland, inflammatory cell infiltration, and changes in the turbinate bones and mucosa were examined. Results: Total turbinate thickness, turbinate bone thickness and mucosal thickness were statistically significantly lower in Group 2 compared to Group 1 (for all, p<0.01). There was a statistically significant increase in the total turbinate thickness, turbinate bone thickness and turbinate mucosa thickness of the rabbits that we treated with G-CSF (Group 3), compared to the rabbits that we created an atrophic rhinitis model and did not give treatment (Group 2) (for all, p<0.01). Discussion: We obtained findings supporting the use of G-CSF as an easy-to-apply treatment method in the medical treatment of atrophic rhinitis.