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    Anthelmintic Activity of Nigella sativa against Caenorhabditis elegans
    (Horizon Research Publishing, 2021) Sen, Emine; Ogut, Tugce; Olgun, Abdullah; Kisa, Ozgul
    Increasing resistance against classical anthelmintic drugs makes discovering new anthelmintic compounds from natural plants important. Nigella sativa (N. sativa) is used as a medicinal plant overall the world and is known to have anthelmintic activity. Caenorhabditis elegans (C. elegans), a common cost-effective model organism that is easily maintained, is useful to determine the anthelmintic activity of new compounds derived from natural products. In our study we aimed to evaluate through toxicity assays the nematocidal activity of N. sativa on C. elegans during its larval and adult stages. Different concentrations of N. sativa oil (900, 450 and 270 mg/mL) were tested and toxicity assessments were done under stereomicroscope by counting the number of surviving nematodes. This study showed that N. sativa essential oil significantly decreases survival of C. elegans in both larval and adult stages at 900 mg/mL final concentration. Larval-stage worms were more sensitive to N. sativa essential oil than were adults. We recommend further studies on other effects of N. sativa on C. elegans after removing the toxic compound(s) from the extract. The further discovery of N. sativa essential oil compounds responsible for anthelmintic activity and determination of their mechanisms of toxicity can pave the way toward new medicines.
  • Küçük Resim
    Öğe
    Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study
    (2022) Aksoy, Nilay; Sen, Emine; Sukmasari, Susi; Özakpınar, Özlem Bingöl; Arıcıoğlu, Feyze; Yücel, Yasemin Yücel; Dumlu, Muhammet Rıdvan; Doolaanea, Abd Almonem; AbdulRahman, Mohammad Nasrin; Olgac, Vakur; Bozkan, Pırıl; Ozen, Bugra
    Purpose The study aimed to evaluate the possible preventive efect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the ffth day of the study, the cheek and sublingual mucosa were irritated by external superfcial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-infammatory markers and biochemical tests were analyzed. Signifcant diferences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-infammatory parameters. Conclusion The preventive efect of 3% gel was signifcant, with no mortality rate, making it an option for preventive strategies..
  • [ X ]
    Öğe
    Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study (vol 148, pg 2153, 2022)
    (Springer, 2022) Aksoy, Nilay; Sen, Emine; Sukmasari, Susi; ozakpinar, ozlem Bingol; Aricioglu, Feyze; Yucel, Yasemin Yucel; Dumlu, Muhammet Ridvan
    [No abstract available]