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    Öğe
    Antibacterial nano cerium oxide/chitosan/cellulose acetate composite films as potential wound dressing
    (Pergamon-Elsevier Science Ltd, 2020) Kalaycıoğlu, Zeynep; Kahya, Nilay; Adımcılar, Veselina; Kaygusuz, Hakan; Torlak, Emrah; Akın-Evingür, Gülşen; Erim, F. Bedia
    Novel chitosan and cellulose acetate polymer composites with nanosized cerium oxide were prepared as potential wound dressing materials. Chitosan and cellulose acetate are natural polymer derivatives with biocompatible properties. Both polymers can be dissolved in formic acid. The polymer composite was formed by solvent-casting method. The formed films were not soluble in water. In order to improve antibacterial, thermal, and mechanical properties of the composite material, films were loaded with nanosized cerium oxide. Films were characterized with thermogravimetric, scanning electron microscopy with energy-dispersive X-ray spectroscopy, mechanical, ultraviolet-visible light transmittance, water solubility, pH, moisture content, water vapor transmission rate, swelling, and antibacterial tests. The physical properties and antibacterial characteristics of the films are promising for further research as a potential wound covering material.
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    Öğe
    Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing
    (2024) Orhan, Burcu; Karadeniz, Duygu; Kalaycıoğlu, Zeynep; Kaygusuz, Hakan; Torlak, Emrah; Erim, F. Bedia
    Foam-based wound dressing materials produced by dispersing gas phases in a polymeric material are soft, adapt to the body shape, and allow the absorption of wound exudate due to their porous structure. Most of these formulations are based on synthetic substances such as polyurethane. However, biopolymers have entered the field as a new player thanks to their biocompatible and sustainable nature. Incorporating biopolymers in formulations is gaining interest in scientific literature, and we extend this approach by adding antibacterial cerium oxide nanoparticles to biopolymer formulation. We introduce a novel biopolymer composite of carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and cerium oxide nanoparticles (CeO2 NPs), namely PVA-CMC@CeO2. This mixture was first foamed and then cross-linked with sodium tetraborate solution, followed by a freeze-thaw process. After the novel material's spectroscopic, structural, and morphological characterization, we investigated its swelling, drug-delivery, antibacterial, and biodegradability properties PVA-CMC@CeO2 dressing effectively inhibits Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) growth and delivers the antibiotic drug silver sulfadiazine for up to 6 h. The antibacterial properties, good swelling, and drug release profile of the blend material show promising potential in wound care applications.