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    Effect of agmatine on impairment of hippocampal neurogenesis and neuroinflammation in streptozotocin-induced diabetes
    (Elsevier, 2019) Zortul, H.; Arıcıoğlu, F.; Hafez, G.; Yazır, Y.; Utkan, T.
    Background: Diabetes mellitus (DM) is associated with modest impairments in cognition. Common molecular pathways to cellular and metabolic dysfunction have been implicated in both DM and cognitive dysfunctions. It has been shown in rodent models that cognitive impairment might be an adverse effect of diabetes. These models are being increasingly used to study pathogenesis and to develop new treatments [1,2]. Agmatine is an endogenous guanidoamine produced from L-arginine in many organs, including brain. Studies suggest that agmatine could be regarded as a neurotransmitter and shown to facilitate memory and learning in rats, in scopolamine-induced amnesia, streptozotocin (STZ)-induced Alzheimer model and chronic stress-induced depression [3]. Hence, the present study was conducted to examine the effect of agmatine as a possible antidiabetic agent in STZ-induced diabetes mellitus (DM) model in rats by evaluating cognitive functions, molecular mechanisms of neuroinflammation and neuroplasticity besides histological changes due to astrosit/microglial activation.