2020 - Cilt 2 - Sayı 1
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Öğe Treatment of iatrogenic factor related gingival recession: A case report(Altınbaş Üniversitesi, 2020) Özenci, İlknur; İpçi, Şebnem Dirikan; Çakar, Gökser; Yılmaz, SelçukRecent reports in the literature show that the application of coronally advanced flap i n c ombination with subepithelial connective tissue graft in the treatment of Miller Class II and even III gingival recessions leads to successful results. This case report describes the use of subepithelial connective tissue graft and enamel matrix derivative combination with coronally advanced flap for the treatment of localized gingival recession caused by an ill-fitting crown restoration. The restorative treatment comprised of the retreatment of the endodontic and restorative needs. At 12 months, successful root coverage with 3.5 mm attachment gain was achieved. The patient had minimal discomfort and was satisfied with esthetic results. This case encourages the usage of subepithelial connective tissue graft, enamel matrix derivative and coronally advanced flap combination in localized Miller Class III gingival recessions. Even though the treatment of Miller Class III gingival recessions are challenging due to loss of interproximal bone and soft tissues, the application of subepithelial connective tissue graft in combination with the use ofenamel matrix derivative has shown to be a predictable treatment procedure in esthetic areas forroot coverage and gain of clinical attachment in single Miller Class III recession defects.Öğe A comparative analysis of biofilm characteristics of Dual-Species periodontopathogenic biofilm based on fusobacterium nucleatum and the Dual-Species biofilm response in the presence of antimicrobial peptide(Altınbaş Üniversitesi, 2020) Keskin, MutluFusobacterium nucleatum (F.nucleatum), which acts as a linking periodontopathogenic bacteria, has the ability of coaggregation with early and late colonization species. It is the most intense gram-negative bacteria found in periodontal health and increases in periodontal diseased areas numerically. In this study, comparative analyses of dual and mono-biofilm structural characteristics formed by Porphyromonas gingivalis and Prevotella intermedia with F. nucleatum have been evaluated. In all results, more biofilm formation was observed in dual-species compared to monospecies biofilms. Biofilm formation of F. nucleatum-P.intermedia has increased in the presence of Human Neutrophilic Peptide (HNP-1). In this study it is concluded that dual-periodontopathogenic coaggregations based on F. nucleatum could produce more intense biofilm structure than single-species ones, and the increase in dual-species biofilm mass in the presence of low doses of HNP-1 may be a defense mechanism of dual periodontopathogenic biofilm.Öğe Epigenetic approach in forensic age estimation(Altınbaş Üniversitesi, 2020) Karadayı, Şükriye; Sezgin, Nurdan; Karadayı, BeytullahAge estimation study is a very important research area that contributes to the solution of the forensic case by helping to identify the identity in forensic sciences. Human age estimation in the traditional way is performed by analysis of bony marks on bones and teeth. An analysis of the age estimation of biological samples from the use of genetic analysis has not yet become part of routine practice. The use of genetic analyses for forensic purposes started with the Restriction Fragment Length Polymorphism (RFLP) analysis in the late 1980s and developed with Short Tandem Repeats (STR) analysis. Along with the technological developments in forensic genetics, progress has continued with single nucleotide polymorphism (SNP) analysis, which enables the identification of hair, eye and skin color and geographic infrastructure of an unknown sample in forensic case resolution. However, recent studies in forensic genetics have focused on epigenetic mechanisms and it has been discovered that DNA methylation can be used in case resolution for forensic age estimation. With the development of DNA methylation studies, a quantitative statistical relationship has been established between DNA methylation and different age groups. T he r esults have been obtained with ± 3-4 age prediction accuracy using DNA methylation markers (CpG regions) tested to date with different methodological approaches. Thus, with the advancement of epigenetic studies in the fields of forensic sciences, the phenotypic features of the DNA of the evidence samples have been estimated with some error rates. The aim of this study is to reveal the latest developments in the field of epigenetics and evaluation of the use of epigenetic-based age estimates for forensic purposes.Öğe Medication related osteonecrosis of the jaws(Altınbaş Üniversitesi, 2020) Özbayrak, Semih; Okumuş, ÖzlemMedication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction, including of bone destruction in the jaws. Osteonecrosis of the jaws can be caused by two pharmacological agents: antiresorptive (including bisphosphonates (BPs) and receptor activator of nuclear factor kappa-B ligand [RANK-L] inhibitors) and antiangiogenic. Among the drugs associated with the development of MRONJ, BPs are the most widely used for a wide variety of clinical indications. Bisphosphonates are used in bone metabolism-related diseases such as Paget’s disease, fibrous dysplasia, osteogenesis imperfecta, but mainly in lung, prostate, breast carcinomas, multiple myeloma and osteoporosis. The effect of the drug depends on the dose and duration of administration. Epidemiological studies showed that long-term use of these drugs may increase the risk of MRONJ development. The purpose of this review is to define the current information about MRONJ, the management strategies and preventive measures.Öğe Restoration of endodontically treated teeth: A review of direct restorative approach(Altınbaş Üniversitesi, 2020) Şişmanoğlu, SonerMany studies have been conducted on the restorative treatment of endodontically treated teeth, but there is still no consensus. At the same time, restorations of endodontically treated teeth can be very challenging. This article focuses on the characterization of endodontically treated teeth, their pre-restorative assessments and approaches for making more successful restorations with current novel direct restorative materials.
