Application of tramadol hydrogel as a transdermal drug delivery with sonophoresis device to rats

Basit Öğe Kaydı
dc.authorid0000-0003-3966-4333en_US
dc.authorid0000-0002-3266-582Xen_US
dc.authorid0000-0002-9788-1101en_US
dc.authorid0000-0002-2479-1236en_US
dc.contributor.authorŞahin, Sitem Merve
dc.contributor.authorDuman, Gülengül
dc.contributor.authorGenç, Ece
dc.contributor.authorYaman, Alper
dc.contributor.authorAltunok, Elif Çiğdem
dc.date.accessioned2021-06-14T08:30:36Z
dc.date.available2021-06-14T08:30:36Z
dc.date.issued2020en_US
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractTransdermal drug delivery offers an appealing alternative to injections and oral medications. However, applications of transdermal drug delivery are constrained to only a few drugs due to low skin permeability. Application of low‐frequency ultrasound enhances skin permeability, a phenomenon called as low‐frequency sonophoresis. The skin consists of two important layers called epidermis and dermis, which are on the fatty layer called hypodermis (subcutaneous tissue). The epidermis is the outermost layer of the skin. It consists mainly of cells called “keratinocytes”. This is caused by the evolution of cells formed in the lower layer and their accumulation on top of each other. At the top is the stratum corneum epidermidis layer from almost completely dead cells. Stratum corneum acts as a primary barrier to drug delivery, transdermal drug delivery technique precedes to conventional drug delivery process. In this study, tramadol hydrogel is an opioid-like analgesic with much less adverse impact was carried out to rat skin. The tramadol hydrogel was applied on rat skin by using a novel developed sonophoretic device. There were 4 groups of Sprague Dawley male rats that were examined to evaluate analgesia. The first group was control group, the second was intraperitoneal (i.p.) application group, the third was tramadol hydrogel without sonophoresis application and the last group was tramadol hydrogel with sonophoresis application. It was shown that tramadol used with sonophoresis increased analgesic effect three-fold than tramadol hydrogel group 30 minutes later. Hotplate analgesia meter was used and the efficacy was measured on 16 rats. Tramadol dosage was 28 mg per kilogram for each rat. Low frequency sonophoresis device transducer was adjusted to 40 kilohertz (kHz) frequency for up to 60 minutes. Measurements were carried out at 0, 10, 20, 30, 40 and 60 minutes. There was a statistically significant difference between tramadol hydrogel and tramadol hydrogel with sonophoresis groups (p 0.05, by Kruskal Wallis test). Moreover, the developed sonophoretic device application was successful and application low frequency 40 kHz was safe. Neither burn nor erythematous streaks were observed on rat skin by using low frequency sonophoresis. The administration of tramadol hydrogel and tramadol hydrogel with sonophoresis groups were examined, the absorption of tramadol increased by 2-3 times transdermally.en_US
dc.identifier.citationŞahin, S. M., Duman, G., Genç, E., Yaman, A., & Altunok, E. Ç. (2020). Application of tramadol hydrogel as a transdermal drug delivery with sonophoresis device to rats. Aurum Journal of Health Sciences, 2(Supplement 1 (Congress issue)), 5-18.en_US
dc.identifier.endpage18en_US
dc.identifier.issn2651-2815
dc.identifier.issueKongre Özel Sayısıen_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2066
dc.identifier.volume2en_US
dc.language.isoen
dc.publisherAltınbaş Üniversitesien_US
dc.relation.ispartofAURUM Journal Health Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTramadol Hydrogelen_US
dc.subjectHot Plate Analgesia Testen_US
dc.subjectSonophoresis Deviceen_US
dc.subjectTransdermal Drug Deliveryen_US
dc.subjectSpraque Dawley Ratsen_US
dc.subjectLow Frequencyen_US
dc.titleApplication of tramadol hydrogel as a transdermal drug delivery with sonophoresis device to rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
SİTEM MERVE ŞAHİN-sayfalar-13,26.pdf
Boyut:
68.52 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/ Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

2020 - Cilt 2 - Sayı Supplement 1 (Congress issue)