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Öğe A meta-analysis assessing the prevalence of drug-drug interactions among hospitalized patients(2023) Aksoy, Nilay; Öztürk, NurPurpose: Drug-drug interactions (DDIs), particularly in hospitalized patients can result in adverse drug events and unfavorable health consequences. The aim of this meta-analysis is to provide up-to-date evidence on the prevalence of clinically evident adverse drug events due to DDIs in hospitalized patients. Methods: Data from Scopus, PubMed, Cochrane and Web of Science were extracted using these keywords (Drug interaction/drug-drug interactions, Hospital/ hospitals, Adverse drug event, Hospitalized patients, inpatient, Department, Hospital stay, Harm, Mortality, death). The studies that include Observational studies on hospitalized patients, reporting potential DDIs using an electronic database, and reporting the clinically observed adverse drug interactions (ADI) through symptoms, signs or Laboratory tests are included. Using Open meta-Software (version 12.11.14), the incidence of clinically evident DDIs among hospitalized patients was determined and shown in a forest plot. Results: Only 15 of the 8261 articles found through a literature search met the inclusion criteria and reported the desired outcome. The pooled prevalence of potential drug-drug interactions is 64.9% (CI 95% 0.618-0.736). While clinically evident DDIs have a pooled frequency of 17.17% (CI 95% 0.133-0.256). Conclusion: The issue of DDIs remains a significant concern in hospitalized patients, with a notable rise in their prevalence. This meta-analysis encompassed a greater quantity of studies and demonstrated a heightened proportion of drug-drug interaction prevalence in comparison to the percentages reported in the previously published meta-analysis.Öğe A multi-center retrospective analysis of healthcare workers after COVID-19: Epidemiological and clinical features(2022) Derin, Okan; Aksoy, Nilay; Çaydaşı, Özge; Yılmaz, Mesut; Mert, AliObjective: Concerns regarding the high-level risk of infection among healthcare workers (HCWs) increased after COVID19 was declared as a pandemic in March 2020. Inadequate infection control owing to a shortage of personal protective equipment or an inconvenient usage of infection control measures may play a significant role in transmission to/among healthcare personnel. The study aimed to determine the characteristics and outcomes of COVID-19 patients who are healthcare workers along with possible transmission routes of COVID-19 in four different healthcare facilities in Istanbul. Methods: All hospital records were reviewed retrospectively. Demographic and clinical characteristics of HCWs were documented, and all infected HCWs were subjected to a phone-based mini-questionnaire and three-dimensional test (TDT). All statistical analyses were done using statistical packages SPSS Demo Ver 22 (SPSS Inc. Chicago, IL, USA). Results: Clinical features of COVID-19 were similar to the general public’s characteristics. The most frequent symptoms were cough, fever, and headache. HCWs with the O blood group tend to have asymptomatic COVID-19 infection. Hospital workers other than medical professionals have a lack of convenience of infection control measures. The median duration of PCR negativity was 9 days. HCWs who had a sore throat at the beginning of COVID-19 have a longer PCR-positive duration. Conclusion: Understanding the clinical features or characteristics of asymptomatic COVID-19 carriers may aid in the implementation of a feasible screening program for early detection. It is strongly advised that proper infection control precautions, education, and auditing of nonclinical staff be implemented. As a result, transmission among healthcare workers can be avoided.Öğe Addressing the gap between pharmacy education and practice(Nova Science Publishers, Inc., 2020) Aksoy, NilayThe heath care process is straggling with complexity, yielding the necessity for multidisciplinary approaches involving all health care providers as well as social scientists and well-rounded pharmacists. The discrepancy between training and practice makes it difficult to undertake these approaches. It has become apparent that pharmacy education needs to respond to professional and social changes and renew its mission in terms of students and learning objectives. "In theory, there is no difference between theory and practice, but in practice there is," stated Manfred Eigen. This chapter will focus on approaches for bridging the theory-practice gap. First of all, these differences can be resolved by carrying out realistic research. Pharmacy institutions should perform advanced research to determine the needs and to promote and support the practice. Numerous literature studies support the proposition to include pharmacists in inter-professional primary health care teams. Country-based research will help confirm whether the training system and education obtained by pharmacy students is sufficient to promote a positive attitude toward potential integration into primary health care. Second, common, clear, and compelling outcomes should be established based on previous studies, and education should be standardized accordingly. A well-rounded student of pharmacy is created by a high-quality pharmacy school, a well-formed curriculum that meets the requirements, and a highly effective style and method of education. The curriculum of apprenticeships should be improved. The enhancement of apprenticeship programs should not be limited to increasing the number of apprenticeship courses, but should also extend to the quality of their content. Simulation training can play an important role in upscaling and improving pharmacy learning productivity and in overcoming the barrier of limited real-field learning. Lastly, the disparity between community-based and hospital-based apprenticeships and the courses attributed to graduates must be reduced to provide compatibility with pharmacy practice. Inter-professional education (IPE) should be introduced into the curriculum. One of the major obstacles to the success of the pharmacist in providing primary health care is presented when the pharmacist is directly involved in patient care and this role is ignored by other health care providers. Inter-professional education prepares students for collaborative thinking and practice. Building this collaborative project through education has a major impact on bridging the gaps between different providers of primary health care. In summary, the recommendations proposed include: continuing professional development (CPD) to enhance the workforce, incorporating technologies and software in pharmacy education, evaluating the education process from different aspects (students, practitioners, primary health care providers), restructuring the curriculum according to research feedback, and finally, effectively collaborating with other health care providers ("One hand can't clap alone"). © 2020 Nova Science Publishers, Inc.Öğe Adherence to the antirheumatic drugs: a systematic review and meta-analysis(2024) Aksoy, Nilay; Öztürk, Nur; Agh, Tamas; Kardas, PrzemyslawIntroduction: This systematic review and meta-analysis aimed to analyze the adherence rate for conventional and biological disease-modifying antirheumatic drugs (DMARDs) utilizing different assessment measures. Method: A systematic literature search was performed in four electronic databases, including PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), covering the time frame from April 1970 to April 2023. Studies that present data on medication adherence among adult patients with rheumatoid arthritis (RA), specifically focusing on DMARDs (conventional or biological), were included in the analysis. The adherence rate for different assessment measures was documented and compared, as well as for conventional and biological DMARDs. A random-effects meta-analysis was performed to assess adherence rates across different adherence assessment measures and drug groups. Results: The search identified 8,480 studies, out of which 66 were finally included in the analysis. The studies included in this meta-analysis had adherence rates ranging from 12 to 98.6%. Adherence rates varied across several adherent measures and calculation methods. Using the subjective assessment measures yielded the outcomes in terms of adherence rate: 64.0% [0.524, 95% CI 0.374-0.675] for interviews and 60.0% [0.611, 95% CI 0.465-0.758] for self-reported measures (e.g., compliance questionnaires on rheumatology CQR-5), p > 0.05. In contrast, the objective measurements indicated a lower adherence rate of 54.4% when using the medication event monitoring system (p > 0.05). The recorded rate of adherence to biological DMARDs was 45.3% [0.573, 95% CI 0.516-0.631], whereas the adherence rate for conventional DMARDs was 51.5% [0.632, 95% CI 0.537-0.727], p > 0.05. In the meta-regression analysis, the covariate "Country of origin" shows a statistically significant (p = 0.003) negative effect with a point estimate of -0.36, SE (0.12), 95% CI, -0.61 to -0.12. Discussion: Despite its seemingly insignificant factors that affect the adherence rate, this meta-analysis reveals variation in adherence rate within the types of studies conducted, the methodology used to measure adherence, and for different antirheumatic drugs. Further research is needed to validate the findings of this meta-analysis before applying them to clinical practice and scientific research. In order to secure high reliability of adherence studies, compliance with available reporting guidelines for medication adherence research is more than advisable.Öğe Assessment of primary health-care providers’ knowledge of Alzheimer’s disease in Turkey(Emerald Publishing, 2024) Ayhan, Yunus Emre; Özmen, Muhammet; Öztürk, Nur; Aksoy, NilayPurpose: Alzheimer’s disease (AD) is the primary cause of dementia in elderly people and needs extensive professional care. The aim of our study was to assess the level of knowledge among primary health-care providers, primarily Family Physicians (FPs) and community pharmacists (CPs), about AD and its treatment. Design/methodology/approach: A cross-sectional study using Google Forms sent by email or message to FPs and CPs in Istanbul in June–July 2023. Turkish modified the Alzheimer’s Disease Knowledge Scale (ADKS) and Alzheimer’s Medicines Knowledge Level Questionnaire (AMKLQ) were used in this study. Findings: A total of 63 FPs with a mean age of 35.3 ± 7.8 and 138 CPs with a mean age of 38.6 ± 12.6 enrolled in the study. There was no statistically significant difference between FPs and CPs in terms of total ADKS score (19.82 ± 2.30 vs 19.23 ± 3.08, p = 0.136), but there was a significant difference in terms of total AMKLQ score (4.31 ± 1.40 vs 3.81 ± 1.49, p = 0.020). Health-care providers with Alzheimer’s training had a higher total AMKLQ score (OR =1.08 CI 95% [1.03–1.14], p = 0.012). Originality/value: FPs’ knowledge of AD is on par with that of CPs. Nevertheless, it has been observed that FPs have more proficiency in delivering accurate responses to the AMKLQ and ADKS inquiries, which encompass crucial details regarding the treatment of AD. The sole determinant of the highest mean AMKLQ score was found to be professional education. Collectively, these arguments emphasize the need for primary health-care practitioners to obtain comprehensive and ongoing education regarding AD and its treatment.Öğe Barriers to healthcare access and continuity of care among Ukrainian war refugees in Europe: findings from the RefuHealthAccess study(2025) Kardas, Przemyslaw; Mogilevkina, Iryna; Aksoy, Nilay; Agh, Tamas; Garuoliene, Kristina; Lomnytska, Marta; Istomina, Natalja; Urbanavice, Rita; Wettermark, Björn; Khanyk, NataliiaIntroduction: The Russian invasion of Ukraine displaced over 14 million people. By 2024, around 6 million Ukrainian refugees settled in Europe under the EU Temporary Protection Directive, providing permit of residence, work and health care. This influx strained European healthcare systems, particularly in addressing acute injuries. As the stay of refugees in EU countries prolongs, the management of chronic conditions becomes increasingly important. However, there is limited information available about Ukrainian refugees' access to various healthcare services. Aim: The aim of this study was to evaluate perceived accessibility of healthcare services in Europe for Ukrainian war refugees and to identify barriers to healthcare access, in order to inform improvements in healthcare provision. Methods: A cross-sectional online survey was conducted across Europe from July 2023 to April 2024, targeting adult Ukrainian war refugees. Survey explored areas defined as key health care needs. Descriptive, parametric and non-parametric statistical analysis methods were employed in data analysis. Results: Of 659 respondents, 550 (83.4%) were included in the final analysis due to having reported need to use healthcare services in the past year. The most prevalent needs included dental care (82.9%), prescription medication (81.6%), care for acute (78.4%), and chronic conditions (64.0%). Perceived access to care varied across services, with vaccinations rated highest, while chronic condition care rated lowest. Around ¼ of respondents reported that they had to temporarily return to Ukraine for services not available in the countries where they stayed, these being mostly dental and gynaecologic care. The most prevalent barriers reported were long waiting times (64.2%), information barriers (55.5%), and high service costs (49.1%). Discussion: The survey identified several barriers in the access to healthcare system for Ukrainians, particularly for chronic conditions care. Some barriers may be subjective, relating to limited access to information. However, others point to potential shortcomings within national healthcare systems, suggesting areas that require further review and improvement. Conclusions: Addressing language barriers, improving information dissemination, and enhancing chronic condition management were identified as crucial for improving healthcare access for Ukrainian war refugees. Coordinated strategies are needed to support refugees and ensure the sustainability of host healthcare systems.Öğe Barriers to healthcare access and continuity of care among Ukrainian war refugees in Europe: findings from the RefuHealthAccess study(FRONTIERS MEDIA SA, 2025) Kardas, Przemyslaw; Mogilevkina, Iryna; Aksoy, Nilay; Agh, Tamas; Garuoliene, Kristina; Lomnytska, Marta; Istomina, Natalja; Urbanavice, Rita; Wettermark, Björn; Khanyk, NataliiaIntroduction: The Russian invasion of Ukraine displaced over 14 million people. By 2024, around 6 million Ukrainian refugees settled in Europe under the EU Temporary Protection Directive, providing permit of residence, work and health care. This influx strained European healthcare systems, particularly in addressing acute injuries. As the stay of refugees in EU countries prolongs, the management of chronic conditions becomes increasingly important. However, there is limited information available about Ukrainian refugees' access to various healthcare services. Aim: The aim of this study was to evaluate perceived accessibility of healthcare services in Europe for Ukrainian war refugees and to identify barriers to healthcare access, in order to inform improvements in healthcare provision. Methods: A cross-sectional online survey was conducted across Europe from July 2023 to April 2024, targeting adult Ukrainian war refugees. Survey explored areas defined as key health care needs. Descriptive, parametric and non-parametric statistical analysis methods were employed in data analysis. Results: Of 659 respondents, 550 (83.4%) were included in the final analysis due to having reported need to use healthcare services in the past year. The most prevalent needs included dental care (82.9%), prescription medication (81.6%), care for acute (78.4%), and chronic conditions (64.0%). Perceived access to care varied across services, with vaccinations rated highest, while chronic condition care rated lowest. Around ¼ of respondents reported that they had to temporarily return to Ukraine for services not available in the countries where they stayed, these being mostly dental and gynaecologic care. The most prevalent barriers reported were long waiting times (64.2%), information barriers (55.5%), and high service costs (49.1%). Discussion: The survey identified several barriers in the access to healthcare system for Ukrainians, particularly for chronic conditions care. Some barriers may be subjective, relating to limited access to information. However, others point to potential shortcomings within national healthcare systems, suggesting areas that require further review and improvement. Conclusions: Addressing language barriers, improving information dissemination, and enhancing chronic condition management were identified as crucial for improving healthcare access for Ukrainian war refugees. Coordinated strategies are needed to support refugees and ensure the sustainability of host healthcare systems. CopyrightÖğe Clinical and economic consequences of medication nonadherence: a review of systematic reviews(Frontiers Media, 2025) Achterbosch, Maria; Aksoy, Nilay; Obeng, George D.; Ameyaw, David; Agh, TamasBackground: Medication efficacy observed in clinical trials may differ from its effectiveness during real-world usage. Medication nonadherence is one of the key factors being responsible for this efficacy-effectiveness gap. The World Health Organization estimated that only 50% of chronic medication users is adherent and nonadherence results in both negative health outcomes for the patient and higher societal costs. An overview of the consequences across disease groups may allow some comparison and could contribute to identification of priority clinical areas. Objective: We aimed to provide an overview the impact of nonadherence on clinical and economic outcomes. Method: We narratively reviewed systematic reviews published between 2014 and 2024 on the effect of medication nonadherence on clinical and economic outcomes. Results: Overall, 43 systematic reviews were identified, including over 410 original studies on clinical outcomes and 174 on economic outcomes, covering different clinical areas (e.g., organ transplantation, cardiovascular diseases, diabetes, depression and chronic lung diseases [asthma/COPD]). Beyond diminished treatment effects, medication nonadherence has been associated with elevated mortality, increased healthcare utilization (including hospital admissions), and higher direct (e.g., more healthcare provider visits) and indirect financial cost burden (e.g., work productivity losses due to absenteeism and presenteeism) for patients and society. Conclusion: Medication nonadherence is associated with poor clinical and economic outcomes across disease areas. Given the significant impact of nonadherence, raising awareness among healthcare professionals and policymakers, early stakeholder engagement in intervention design, and eventually implementation of cost-effective interventions on both health policy, system and individual patient level are urgently required.Öğe COVID-19 lockdown effects on sleep, immune fitness, mood, quality of life, and academic functioning: Survey data from Turkish university students(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Hendriksen, Pauline A.; Tan, Sema; van Oostrom, Evi C.; Merlo, Agnese; Bardakçi, Hilal; Aksoy, Nilay; Garssen, Johan; Bruce, Gillian; Verster, Joris C.Previous studies from the Netherlands, Germany, and Argentina revealed that the 2019 coronavirus disease (COVID-19) pandemic and associated lockdown periods had a significant negative impact on the wellbeing and quality of life of students. The negative impact of lockdown periods on health correlates such as immune fitness, alcohol consumption, and mood were reflected in their academic functioning. As both the duration and intensity of lockdown measures differed between countries, it is important to replicate these findings in different countries and cultures. Therefore, the purpose of the current study was to examine the impact of the COVID-19 pandemic on immune fitness, mood, academic functioning, sleep, smoking, alcohol consumption, healthy diet, and quality of life among Turkish students. Turkish students in the age range of 18 to 30 years old were invited to complete an online survey. Data were collected from n = 307 participants and included retrospective assessments for six time periods: (1) BP (before the COVID-19 pandemic, 1 January 2020–10 March 2020), (2) NL1 (the first no lockdown period, 11 March 2020–28 April 2021), (3) the lockdown period (29 April 2021–17 May 2021), (4) NL2 (the second no lockdown period, 18 May 2021–31 December 2021), (5) NL3 (the third no lockdown period, 1 January 2022–December 2022), and (6) for the past month. In this data descriptor article, the content of the survey and the dataset are described.Öğe Evaluating the Antibiofilm Effects of Antibiotics on Staphylococcus Species from Pediatric Hematology-Oncology Patients(2025) Vatansever, Cansu; Aksoy, Nilay; Adaklı Aksoy, Başak; Fışgın, TunçBiofilms are microbial communities and occur on different medical devices such as catheters. The formation of bacterial biofilms on medical devices leads to indwelling medical device-related infections. Since biofilm bacteria are more resistant to antibiotics than planktonic bacteria, using these antibiotics in indwelling medical device-related infections causes recurrence of infections, treatment failure, and death. Minimum inhibitory concentration (MIC) is an important reference in treating acute infections caused by planktonic bacteria. However, MIC is ineffective in indwelling medical device-related infections caused by biofilm bacteria. The study aims to demonstrate the necessity and development of effective and standard methods such as minimum biofilm prevention concentration, minimum biofilm inhibitory concentration, and minimum biofilm eradication concentration in the case of indwelling medical device-related infection. The study was conducted with 10 isolates of Staphylococcus species from patients who developed infections in the Pediatric Hematology-Oncology Department at Medical Park Bahcelievler Hospital. According to the study results, even if planktonic bacteria are sensitive to antibiotics, they can become resistant to this antibiotic when they are in a biofilm (p < 0.05, Crosstab). Also, inhibiting the growth of planktonic bacteria does not prevent biofilm formation. The study additionally revealed that inhibiting and eradicating biofilm is more difficult than preventing biofilm formation (p < 0.05).Öğe Evaluation of antidepressant medication use and determination of risk factors for depression among university students in İstanbul(Altınbaş Üniversitesi, 2021) Yıldız, Ecem; Aksoy, Nilay; Umar, RashidaDepression is one of the most common mental health illnesses that can get worse without proper medical interventions. Estimates of the depression prevalence among university students occupy a fair portion of the general depressed populations. This study aimed to assess the prevalence of depression among university students and identifying their characteristics. The conducted cross-sectional study obtained data from different schools located in Istanbul. The highest participation in the study was from Altınbaş, Istanbul, Yeni Yüzyıl and Istinye Universities. The other universities are Yeditepe, Maltepe, Biruni, Istanbul Technical, Yıldız Technical, Bezmialem, Istanbul Kültür, Beykent and Marmara Universities. This study was conducted between December 2019 and March 2020 after the ethical committee approval. A total of 286 students were included in the study. 75% were female and the mean age and standard deviation (SD) of the students was 21.79 ± 1.775 years. Based on ‘Beck Depression Inventory’, the depressive state was observed to be no or minimal in 59%, mild in 20%, moderate in 16%, and severe in 5% of the participants. The student-related factors, such as the type of the school, cultural-social-financial issues were among the most factors that affect the incidence of depression in students. The students included in this study had only few information about depression and antidepressants which is not enough to understand the whole concept of depression and antidepressants.Öğe Evaluation of clinical pharmacy services in pediatric nephrology service(Springer, 2021) Gun, Zeynep Ulku; Aksoy, Nilay; Tabel, Yilmaz; Sancar, Mesut[No abstract available]Öğe Evaluation of educational needs of diabetic patients(University of Ankara, 2022) Aksoy, Nilay; Öztürk, Nur; Ulusoy, Serel; Umar, Rashida Muhammad; Özaydın, SenaObjective: Our study aimed to assess the role of pre-graduate pharmacy students’ participation in a diabetic education program on improving diabetic self-care. Material and Method: Thisstudy included both a cross-sectional and a longitudinal follow-up. Altinbas University fifth-year pharmacy students gathered relevant information from diabetic patients that visited community pharmacies, under the supervision of their instructor pharmacist. The participants filled out the diabetic self-care scale on their first visit before they were given the education. Patients refilled the same selfcare questionnaire after three months. Statistical package for the social science (SPSS) 26 was used for all statistical analysis. Result and Discussion: The study comprised 86 diabetic patients. The second questionnaire results showed significant improvement in all patients. The total diabetic self-care scale scores were improved remarkably after the training session. HbA1c and BMI values decreased significantly. An educational program can improve diabetic self-care and diabetic outcomes. Active participation of final year pharmacy students in patient care can also improve pharmacists' participation and contribution to patient care deliveryÖğe Identifying and presenting key country-specific indicators related to medication adherence: a comprehensive study across European countries(2024) Agh, Tamas; Garuoliene, Kristina; Granas, Anne Gerd; Gregorio, Joao; Aksoy, Nilay; Khanyk, Nataliia; Hadziabdic, Maja Ortner; Kardas, Przemyslaw; European Network to Advance Best Practices and Technology on Medication Adherence (ENABLE) CollaboratorsThis study tackles the critical challenge of medication non-adherence in healthcare by pinpointing indicators related to medication adherence (IRMAs) across 39 European countries and Israel. Utilizing a structured expert survey methodology within the European Network to Advance Best Practices and Technology on Medication Adherence (ENABLE; COST Action CA19132), our research identified key country-specific IRMAs and collected data on these indicators to understand the multifaceted nature of medication adherence. The research was conducted in two phases: firstly, defining key IRMAs through a two-round expert survey, and secondly, gathering country-specific data on these IRMAs through literature reviews and additional expert surveys. The study revealed a diverse range of 26 top-ranked IRMAs, including six related to country characteristics, four to social/economic factors, three each to therapy-related and patient-related factors, one to condition-related factors, and nine to healthcare system-related factors. The availability of country-specific data on these IRMAs varied among the countries, highlighting the need for more comprehensive data collection and research. The findings from this study not only underscore the complexity of predicting medication adherence but also lay the groundwork for developing targeted, country-specific interventions to improve adherence. Moreover, this research offers valuable insights for policymakers, highlighting the importance of understanding the multifaceted nature of medication adherence and offering a valuable resource in formulating targeted health policies to enhance health outcomes and reduce the economic burden associated with medication non-adherence.Öğe Integration of a virtual pharmacy simulation program “MyDispense” in clinical pharmacy education(PharmacyEducation, 2021) Aksoy, Nilay; Öztürk, NurSince the outbreak of coronavirus disease (COVID-19) and with the absence of conventional social interactions, artificial intelligence and simulation become essential part of sustaining productivity around the world. MyDispense, an online pharmacy simulation, allows students to experience real-life situations in a virtual professional setting to behave as a pharmacist and undertake professional tasks. Aim: The study aim was to see how MyDispense influenced pharmacy students' clinical pharmacy education outcomes. Methods: A questionnaire was used to assess satisfaction, confidence and motivation, clinical experience, and decision-making among 81 students ofboth genders pre and post the practice. Results:Pre and post-test differences in all four dimensions of the questionnaire were statistically significant (p<0.05). Conclusion: The results obtained from this study indicate a collective improvementin the field-related knowledge of the participants, enhanced medication management performance, and a more precise application of clinical tools.Öğe Investigation of ceftazidime-avibactam susceptibility in clinical isolates of gram-negative bacteria(Turkiye Klinikleri, 2022) Dumlu, Rıdvan; Yurttutan Uyar, Neval; Ayaş, Meltem; Aksoy, Nilay; Öztürk, Nur; Kocagöz, Ayşe SesinBackground/aim: Our study investigated the susceptibility rate of ceftazidime-avibactam and the risk factors associated with its resistance by analyzing gram-negative bacteria isolated from various patient samples. Materials and methods: Between March and November 2020, 1119 gram-negative bacteria strains were isolated from patient samples in Acıbadem Healthcare Group hospitals; ceftazidime-avibactam susceptibility results were evaluated using a 10/4µg (Oxoid, UK) disc and evaluated according to Eucast 2020 recommendations. Patient and isolate characteristics that could be risk factors were retrospectively investigated and statistically analyzed using SPSS 25.0. Results: Male patients made up 52% (n = 581) of the study’s total patient population, and they averaged 55.5 ± 24.9 years old. Of 1119 gram-negative strains culture and antibiogram, 1023 (91.4%) were sensitive to ceftazidime-avibactam. An increased risk of resistance was observed with female gender (OR = 2.29; CI 95% [1.45–3.61]; p < 0.05), Pseudomonas aeruginosa (OR = 1.67, CI 95% [1.03–2.7]; p < 0.05), the presence of multidrug-resistance (MDR) (OR = 4.07, CI 95% [2.47–6.7]; p < 0.05) pandrug-resistance (PDR) (OR = 12, (CI) 95% [9.9–14.7] ]; p < 0.05) and admission to intensive care unit (ICU) (OR = 1.89, CI 95% [1.22–2.93]; p < 0.05). Conclusion: The resistance rate of ceftazidime-avibactam was found to be 8.6%, and it was thought that resistant strains produced metallo-ß-lactamase (MBL) type carbapenemase. Risk factors were female gender, Pseudomonas aeruginosa, MDR, PDR, and admission to ICU. Therefore, studying the ceftazidime-avibactam susceptibility test together with gram-negative bacteria identification, especially in groups at risk for resistance, is one of the important factors that can positively affect the success of treatment.Öğe Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study(2022) Aksoy, Nilay; Sen, Emine; Sukmasari, Susi; Özakpınar, Özlem Bingöl; Arıcıoğlu, Feyze; Yücel, Yasemin Yücel; Dumlu, Muhammet Rıdvan; Doolaanea, Abd Almonem; AbdulRahman, Mohammad Nasrin; Olgac, Vakur; Bozkan, Pırıl; Ozen, BugraPurpose The study aimed to evaluate the possible preventive efect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the ffth day of the study, the cheek and sublingual mucosa were irritated by external superfcial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-infammatory markers and biochemical tests were analyzed. Signifcant diferences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-infammatory parameters. Conclusion The preventive efect of 3% gel was signifcant, with no mortality rate, making it an option for preventive strategies..Öğe Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study (vol 148, pg 2153, 2022)(Springer, 2022) Aksoy, Nilay; Sen, Emine; Sukmasari, Susi; ozakpinar, ozlem Bingol; Aricioglu, Feyze; Yucel, Yasemin Yucel; Dumlu, Muhammet Ridvan[No abstract available]Öğe Is ChatGPT reliable and accurate in answering pharmacotherapy-related inquiries in both Turkish and English?(2024) Öztürk, Nur; Yakak, İrem; Ağ, Melih Buğra; Aksoy, NilayIntroduction: Artificial intelligence (AI), particularly ChatGPT, is becoming more and more prevalent in the healthcare field for tasks such as disease diagnosis and medical record analysis. The objective of this study is to evaluate the proficiency and accuracy of ChatGPT in different domains of clinical pharmacy cases and queries. Methods: The study NAPLEX® Review Questions, 4th edition, pertaining to 10 different chronic conditions compared ChatGPT's responses to pharmacotherapy cases and questions obtained from McGraw Hill's, alongside the answers provided by the book's authors. The proportion of correct responses was collected and analyzed using the Statistical Package for the Social Sciences (SPSS) version 29. Results: When tested in English, ChatGPT had substantially higher mean scores than when tested in Turkish. The average accurate score for English and Turkish was 0.41 ± 0.49 and 0.32 ± 0.46, respectively, p = 0.18. Responses to queries beginning with "Which of the following is correct?" are considerably more precise than those beginning with "Mark all the incorrect answers?" 0.66 ± 0.47 as opposed to 0.16 ± 0.36; p = 0.01 in English language and 0.50 ± 0.50 as opposed to 0.14 ± 0.34; p < 0.05in Turkish language. Conclusion: ChatGPT displayed a moderate level of accuracy while responding to English inquiries, but it displayed a slight level of accuracy when responding to Turkish inquiries, contingent upon the question format. Improving the accuracy of ChatGPT in languages other than English requires the incorporation of several components. The integration of the English version of ChatGPT into clinical practice has the potential to improve the effectiveness, precision, and standard of patient care provision by supplementing personal expertise and professional judgment. However, it is crucial to utilize technology as an adjunct and not a replacement for human decision-making and critical thinking.Öğe Knowledge and attitude of students studying at health department towards HPV and HPV vaccination(Elsevier, 2022) Aksoy, Nilay; Öztürk, Nur; Ulusoy, Serel; Ömür, Muhammed FurkanThe human papillomavirus (HPV) is the most common diagnosed sexually transmitted infection in the world. The most frequent disease linked to HPV is cervical cancer as well as other cancers including those of the vulva, vagina, penis, anus, and oropharynx. Our research sought to evaluate the knowledge and attitudes concerning human papillomaviruses and their vaccine among students enrolled in Altınbaş University's faculties of health sciences. Method A cross-sectional study was carried out using a survey containing 41 questions about demographic variables, knowledge, and attitudes toward HPV and HPV vaccines. The questions were distributed to students via Google form using social media applications such as WhatsApp. Results The study involved 144 students, 71.5 % of whom were female. 37.5 % % of the participants learned about HPV from social media. Knowledge of HPV is present in 82 % of females and 25 % of males. Most of the questions had more accurate replies from female than from male students p < 0.05. As a result, 88 %, 46 % of female respondents and 27 %, 14 % of male respondents, respectively, correctly answered the questions about who should receive HPV vaccinations p < 0.001 and how many doses are necessary. Conclusion Participants' awareness of HPV, HPV vaccination, and cervical cancer was rather high when compared to other research. However, there are knowledge gaps that need to be corrected and provided through educational programs.
