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    Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes
    (Royal Soc Chemistry, 2016) Özalp, V. Cengiz; Cam, Dilek; Hernandez, Frank J.; Hernandez, Luiza I.; Schafer, Thomas; Öktem, Hüseyin A.
    A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.