Yazar "Kalayi, Mohammed" seçeneğine göre listele

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    Evaluation of emulgel formulations contain diclofenac sodium via quality by design approach
    (2022) Kalayi, Mohammed; Yeğen, Gizem; Okur, Neslihan Üstündağ; Aksu, Buket
    Emulgel is considered as emulsions, either oil-in-water or water-in-oil type, that is formed via blending with a gelling agent. Their common usage as pharmaceutical dosage form results from the broad utilization of emulsion systems, particularly for dermatological formulations. Quality by Design (QbD) is a scientific, holistic, risk-based, systematic, and proactive approach that starts with predefined objectives and assertiveness on product quality, procedure understanding, and process control. In this study, the QbD approach was implemented in the production of emulgel containing diclofenac sodium and the goal was to build quality into the product from the inception of formulation development. The hydrogel phase and oil phase of emulgel were prepared separately, then mixed. Emulgels were evaluated for their macroscopic, and microscopic examination, pH, electrical conductivity measurements, and viscosity. The optimum formulation was found by using the ANN Modelling program. According to macroscopic evaluation the optimum emulgel was an opaque white color, and homogeneous with no phase separation or grittiness. The viscosity of the optimum formula is 4600, pH value is 6.7, electrical conductivity is 120 µS-1, and particle diameter was also 0,989 µm. Results showed the optimized formula has the required properties. ANN modeling technique has been used to develop a pharmaceutical formulation via determining multivariate relations between independent parameters and quality properties affected by these parameters. Although artificial intelligence programs are not enough to build and develop formulations by itself, they play a significant role in formulation development.
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    Optimization and evaluation of moisturizing cream containing dexpanthenol
    (Altınbaş Üniversitesi, 2023) Barbar, Arkan; Kalayi, Mohammed; Aksu, Buket
    Background/aim: The main purpose of this work was to prepare and evaluate a moisturizing cream containing dexpanthenol.Materials and methods: In this study, several cream formulations were prepared using the oil-inwater (O/W) emulsion technique to investigate the effect of varying concentrations of the independent variable on the physical appearance, pH, electrical conductivity, viscosity and spreadability. Different formulations were prepared with different combinations of Cera alba and Stearic acid with various excipients. The developed formulations were examined with the QbD approach. A process known as "quality by design" uses statistical, analytical, and risk-management techniques in the planning, development, and production of pharmaceuticals to guarantee the predetermined quality of the product. Results: According to the QbD studies, the Design Space is given for optimum formulae. After establishing the model equations for the main effects and responses, various cream formulations containing stearic acid and cera alba were optimized based on spreadability, viscosity, and electrical conductivity. Conclusion: In conclusion, the outcomes of different formulations obtained in this research study clearly showed that a moisturizing cream containing a certain ratio of Cera alba and Stearic acid have an up-and-coming potential. Therefore, proportions of Cera alba and Stearic acid are included in the moisturizing cream to win its cosmetic benefits.