Optimization and evaluation of moisturizing cream containing dexpanthenol
Yükleniyor...
Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Altınbaş Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: The main purpose of this work was to prepare and evaluate a moisturizing cream containing
dexpanthenol.Materials and methods: In this study, several cream formulations were prepared using the oil-inwater (O/W) emulsion technique to investigate the effect of varying concentrations of the independent variable
on the physical appearance, pH, electrical conductivity, viscosity and spreadability. Different formulations were
prepared with different combinations of Cera alba and Stearic acid with various excipients. The developed
formulations were examined with the QbD approach. A process known as "quality by design" uses statistical,
analytical, and risk-management techniques in the planning, development, and production of pharmaceuticals to
guarantee the predetermined quality of the product.
Results: According to the QbD studies, the Design Space is given for optimum formulae. After establishing the
model equations for the main effects and responses, various cream formulations containing stearic acid and cera
alba were optimized based on spreadability, viscosity, and electrical conductivity.
Conclusion: In conclusion, the outcomes of different formulations obtained in this research study clearly showed
that a moisturizing cream containing a certain ratio of Cera alba and Stearic acid have an up-and-coming
potential. Therefore, proportions of Cera alba and Stearic acid are included in the moisturizing cream to win its
cosmetic benefits.
Açıklama
Anahtar Kelimeler
QbD, Dexpanthenol, Spreadability, Textural
Kaynak
AURUM Journal of Health Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
1
Künye
Barbar, A., Kalayi, M., Aksu, B. (2023). Optimization and evaluation of moisturizing cream containing dexpanthenol. AURUM Journal of Health Sciences, 5(1), 9-20.
