2021 - Cilt 3 - Sayı 1
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Öğe Industry 4.0 elements for pharmaceutical development and manufacture(Altınbaş Üniversitesi, 2021) Aksu, Buket; Yeğen, GizemThe innovations of the Industry 4.0 revolution in the New World aim at creating a society where we can solve many problems in every sector and social life. As a condition for Industry 4.0, industrial sectors are heading towards digitalization and automation. Pharmaceutical Industry takes its share in this sense and tries to keep up with this pace in the context of Pharma 4.0 which is a hot topic. However, it is a known fact that developing safe and effective new treatments is a long, difficult, and expensive process, so FDA released the Pharmaceutical cGMPs for the 21st-century report and in this report; it specified Quality by Design (QbD) and Process Analytical Technologies (PAT) initiative to bring a solution. The introduction of the new QbD approach, which advocates providing the quality within the product with design instead of testing, brought an increase in the quality of the products manufactured, a decrease in costs and accelerated the market launch of the medicines. Moreover, patient safety is brought to the fore with better quality medicines and the patient accesses the drug in a shorter time.Öğe A new approach in epilepsy treatment: nano-carrier systems(Altınbaş Üniversitesi, 2021) Yavuz, Burçak; Yıldırım, Özlem; Yılmaz, Ahsen GülizarCentral nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified. It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally, antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective. On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus, support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition to current treatment methods in epilepsy.Öğe The burden of care and coping strategies of caregivers of elderly patients(Altınbaş Üniversitesi, 2021) Köleoğlu, Şerife; Bağlama, Sevgin SamancıoğluThis study was conducted to determine the burden of care and coping strategies experienced by caregivers of elderly inpatients in a palliative care unit and internal medicine services. This study is a descriptive and comparative study. The study sample consisted of 80 caregivers of the elderly hospitalized in the Palliative Care Unit and Internal Medicine Clinic in a city hospital between April and June 2017. The Personal Information Form, the Zarit Caregiver Burden Interview Scale (ZCBI Scale), and Coping Strategies Inventory-Short Form (CSI Short Form) were used in this study. The total score obtained by the caregivers from the ZCBI Scale was 50.37 ± 10.93 in the palliative care unit and 32.72 ± 8.72 in the internal medicine clinic. A significant difference was found between the two groups in terms of the subscales “Planning” and “Searching Social Support-Instrumental” of the CSI Short Form and the total score of ZCBI Scale. Nurses should assess socio-demographic characteristics, financial difficulties, and family relationships that may intensify the burden on caregivers of elderly patients in the palliative care units and facilitate coping strategies.Öğe Evaluation of antidepressant medication use and determination of risk factors for depression among university students in İstanbul(Altınbaş Üniversitesi, 2021) Yıldız, Ecem; Aksoy, Nilay; Umar, RashidaDepression is one of the most common mental health illnesses that can get worse without proper medical interventions. Estimates of the depression prevalence among university students occupy a fair portion of the general depressed populations. This study aimed to assess the prevalence of depression among university students and identifying their characteristics. The conducted cross-sectional study obtained data from different schools located in Istanbul. The highest participation in the study was from Altınbaş, Istanbul, Yeni Yüzyıl and Istinye Universities. The other universities are Yeditepe, Maltepe, Biruni, Istanbul Technical, Yıldız Technical, Bezmialem, Istanbul Kültür, Beykent and Marmara Universities. This study was conducted between December 2019 and March 2020 after the ethical committee approval. A total of 286 students were included in the study. 75% were female and the mean age and standard deviation (SD) of the students was 21.79 ± 1.775 years. Based on ‘Beck Depression Inventory’, the depressive state was observed to be no or minimal in 59%, mild in 20%, moderate in 16%, and severe in 5% of the participants. The student-related factors, such as the type of the school, cultural-social-financial issues were among the most factors that affect the incidence of depression in students. The students included in this study had only few information about depression and antidepressants which is not enough to understand the whole concept of depression and antidepressants.
