A new approach in epilepsy treatment: nano-carrier systems
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Altınbaş Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Central nervous system (CNS) diseases have a very important place in terms of public health. Epilepsy is
one of the most common CNS diseases. Epilepsy is a chronic disease, and it is a cause of substantial morbidity and
mortality. Many people around the world suffer from epilepsy, and the causes of this disease are still not fully clarified.
It is known that approximately 50 million people suffer from epilepsy. Antiepileptic drugs are frequently used in
the treatment of epilepsy, but the difficulty with these drugs is the emergence of drug resistance, and additionally,
antiepileptic drugs can be administered in oral and intravenous routes. But these treatments are not always effective.
On the other hand, drugs used in the treatment of epilepsy must be delivered effectively and safely, so to protect the
brain. Therefore, new delivery systems are needed to deliver drugs at concentrations determined for high therapeutic
efficacy in epilepsy without side effects. Considering this information, there is a need to develop new treatment
strategies. With the development of nanotechnology, it has been shown that nanoparticles as a drug delivery system
are significantly effective in the treatment of diseases. Nano-carrier systems can fulfill many functions such that they
can cross the blood-brain barrier (BBB) passing a specific cell or signaling pathway, reply to endogenous stimulus,
support nerve regeneration, and ensure cell survival. Thanks to these features, it is seen that nano-carrier systems
are quite assertive regarding the current treatment methods in epilepsy. Today, studies of the therapeutic efficacy
of liposomes, micelles, solid lipid nanoparticles, dendrimers, and nanoemulsions as nano-carrier systems on central
nervous system diseases are still ongoing. It holds promise in the concentration control of the drugs and the delivery
of the drug to the target tissue through the BBB. This review investigates the role of nano-carrier systems in addition
to current treatment methods in epilepsy.
Açıklama
Anahtar Kelimeler
Epilepsy, Epidemiology, Nano-Carrier Systems, Nanotechnology
Kaynak
AURUM Journal of Health Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
1
Künye
Yavuz, B., Yıldırım, Ö., & Yılmaz A. G. (2021).A new approach in epilepsy treatment: nano-carrier systems. Aurum Journal of Health Sciences, 3(1), 33-44.
