2019 - Cilt 1 - Sayı 2
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Öğe Rare disease and orphan drug situations in Turkey and around the world(Altınbaş Üniversitesi, 2019) Aksu, BuketDiseases with a prevalence less than 1/2000 are defined as “Rare Diseases”. This group of diseases is a highly heterogeneous group that affects multiple systems. Approximately 80% of these are caused by genetic reasons, and the remaining 20% are caused by environmental factors or are idiopathic. Orphan drug is defined as a medicinal product designed for a life-threatening or chronically impairing rate disease but with a low possibility of obtaining a return on investment due to insufficient sales. In Turkey, where consanguineous marriage frequency is 25% on average, the probability of rare diseases is quite high. Lack of knowledge and specialist physicians, very expensive treatments, and lack of a designated regulation for rare diseases and orphan drugs are the main problems in our country. The research revealed that orphan drugs were imported to Turkey through the Turkish Pharmacists’ Association (TEB) and not covered by Social Security, therefore making it hard for the patients with low income to reach these drugsÖğe Essential oil composition from aerial parts of scolymus hispanicus L.(Altınbaş Üniversitesi, 2019) Servi, HüseyinThe volatile oil composition of Scolymus hispanicus L. was investigated. Essential oil of aerial parts were obtained through hydro-distillation and determined with GC-MS analyses. Fifteen compounds were determined in the oil (99.3%) of aerial part. The main compounds were heneicosane (19.4 %), hexahydrofarnesly acetone (17.0%) and phytol (17.0%). Saturated n-alkane derivatives (35.2%), oxygenated sesquiterpenes (25.6%) and diterpene (17.0%) were dominated in the oil. Also, the antibacterial activity of volatile oil was studied against Escherichia coli and Staphylococcus aureus bacteria. But the oil did not show activity against the tested microorganisms at 80-10 mg/ mL concentrations. Here, it is reported for the first time on the volatile oil composition of S. hispanicus.Öğe Determination of antibacterial effect of punica granatum shell extract(Altınbaş Üniversitesi, 2019) Ada, İpek; Candemir, FatihPunica granatum (Pomegranate) is used as fresh fruit or processed products such as pomegranate juice, pomegranate sour and wine, jam. Although pomegranate is produced in our country, pomegranate shell is discarded without use. In recent studies; P. granatum containing rich phenolic compounds is known to have antibacterial, antifungal and antioxidant activity. The aim of this study was to investigate the antibacterial effect of P. granatum shell extracts prepared by ethanol, methanol and distilled water mixture on bacteria isolated from degraded cheese and salami samples by well diffusion method. In this study, identification of bacteria were performed by API biochemical identification test kits. API® 20 Strep for Listeria monocytogenes, API® 20E for Salmonella typhimurium and API® Staph test kits for Staphylococcus aureus were used. When the results of this study are evaluated, the zone diameters were measured as 18-24 mm and it was determinated that P. granatum shell extract has antibacterial effect against to isolated bacteria from salami and cheese samples.Öğe Recurrence of langerhans cell histiocytosis of jaws: a case report with one year follow-up(Altınbaş Üniversitesi, 2019) Okumuş, Özlem; Olgaç, Vakur; Özbayrak, SemihLangerhans cell histiocytosis (LCH) is an unusual disorder characterized by high proliferation of Langerhans cells. A 27-year-old male patient was referred to the Oral Medicine Clinic, Faculty of Dentistry, Altınbaş University with a complaint of wound that does not heal for eight months. The clinical examination showed palatal mucosal ulceration extending to the bone at the upper right first molar region and ulceration at the lingual mucosa of the lower right first molar. The patient had been previously evaluated by a different dentist and was told that it was an aphthous lesion. A punch biopsy from the palatal mucosa and alveolar mucosa near the lesion revealed Langerhans cells and positive reaction to CD1 so the patient was diagnosed with LCH. The insignificant treatment trials may lead to diagnostic delay. Oral lesions may be the earliest symptom of LCH and in most cases; the oral cavity may be the only area involved. Awareness of lesions in the oral mucosa is important in achieving the accurate and early diagnosis and effective treatment plan.
