Effect of agmatine on impairment of hippocampal neurogenesis and neuroinflammation in streptozotocin-induced diabetes

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dc.contributor.authorZortul, H.
dc.contributor.authorArıcıoğlu, F.
dc.contributor.authorHafez, G.
dc.contributor.authorYazır, Y.
dc.contributor.authorUtkan, T.
dc.date.accessioned2021-05-15T12:41:28Z
dc.date.available2021-05-15T12:41:28Z
dc.date.issued2019
dc.departmentEczacılık Fakültesien_US
dc.description31st Congress of the European-College-of-Neuropsychopharmacology (ECNP) -- OCT 06-09, 2018 -- Barcelona, SPAIN
dc.description.abstractBackground: Diabetes mellitus (DM) is associated with modest impairments in cognition. Common molecular pathways to cellular and metabolic dysfunction have been implicated in both DM and cognitive dysfunctions. It has been shown in rodent models that cognitive impairment might be an adverse effect of diabetes. These models are being increasingly used to study pathogenesis and to develop new treatments [1,2]. Agmatine is an endogenous guanidoamine produced from L-arginine in many organs, including brain. Studies suggest that agmatine could be regarded as a neurotransmitter and shown to facilitate memory and learning in rats, in scopolamine-induced amnesia, streptozotocin (STZ)-induced Alzheimer model and chronic stress-induced depression [3]. Hence, the present study was conducted to examine the effect of agmatine as a possible antidiabetic agent in STZ-induced diabetes mellitus (DM) model in rats by evaluating cognitive functions, molecular mechanisms of neuroinflammation and neuroplasticity besides histological changes due to astrosit/microglial activation.en_US
dc.description.sponsorshipEuropean Coll Neuropsychopharmacolen_US
dc.identifier.doi10.1016/j.euroneuro.2018.11.416
dc.identifier.endpageS261en_US
dc.identifier.issn0924-977X
dc.identifier.issn1873-7862
dc.identifier.startpageS260en_US
dc.identifier.urihttps://doi.org/10.1016/j.euroneuro.2018.11.416
dc.identifier.urihttps://hdl.handle.net/20.500.12939/807
dc.identifier.volume29en_US
dc.identifier.wosWOS:000458400500354
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorZortul, H.
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocin-Induced Diabetesen_US
dc.subjectMWMen_US
dc.subjectmRNA Levels Of NLRP1en_US
dc.titleEffect of agmatine on impairment of hippocampal neurogenesis and neuroinflammation in streptozotocin-induced diabetes
dc.typeConference Object

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