Determination of potentially drug-drug interaction in oncology patients
[ X ]
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background International guidelines are tools
enabling physicians to incorporate the latest evidence based
clinical information into practice. Objective This study aimed
to evaluate the impact of antiemetic guidelines adherence on
the incidence of chemotherapy-induced nausea and vomiting
(CINV) and patient quality of life. Setting Marmara University Pendik Training and Research Hospital chemotherapy
unit, Istanbul, Turkey. Method The study included 100
chemotherapy naive patients. Antiemetic prescribing patterns
and their consistency with MASCC/ESMO 2014 guidelines
were assessed. Patients recorded incidences of vomiting in a
daily dairy and described their nausea using a 7-item Likert
Scale. The incidence of CINV was recorded over five days. To
assess the patient’s quality of life, a modified Turkish version
of the Functional Living Index-Emesis (FLIE) questionnaire
was administered before and after receiving chemotherapy. A
questionnaire on the existence and severity of side effects was
developed and administered. Main outcome measures
Incidence of side effects on CINV and quality of life
according to the FLIE. Results The primary outcome revealed
differences in complete control (no emetic episodes, rescue
therapy or nausea), FLIE scores and side effects. Guidelines
consistency was observed more with acute (A) than with
delayed (D) prevention of CINV, with significant differences
in complete control between the guideline adherent group
(GAG) and the guideline nonadherent group (GNG). Significant differences in the FLIE score were noticed between
GAG(D) and GNG(D), and GNG(D) had a higher incidence
of diarrhoea, headache, swallowing difficulties and darkcoloured stool. Conclusion Consistency with guidelines
resulted in significant reduction in the incidence of both cute
and delayed CINV and other side effects, and with improvement of the patient quality of life.
Açıklama
Anahtar Kelimeler
Drug Interaction, Oncology, Clinical Pharmacist, Chemotherapy
Kaynak
International Journal of Clinical Pharmacy
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
38
Sayı
2
