Optimization of Semi-Solid Lipid Nanoparticle Dispersions by Quality by Design Approach for Dermal Delivery of Curcumin

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dc.contributor.authorBadıllı, Ulya
dc.contributor.authorŞen, Aslı
dc.contributor.authorYeğen, Gizem
dc.contributor.authorÇiloğlu, Berna Güven
dc.contributor.authorAksu, Buket
dc.contributor.authorBeşikçi, Arzu Onay
dc.date.accessioned2025-10-13T14:04:14Z
dc.date.available2025-10-13T14:04:14Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractCurcumin is an important anti-inflammatory agent for the treatment of skin disorders. However, its low water solubility, poor bioavailability, and instability limit the utilization of curcumin. Semi-solid lipid nanoparticle (SLN and NLC) dispersions, which maintain their colloidal particle size despite their high viscosity, offer a novel promising approach with high potential for dermal curcumin delivery. In this study, novel semi-solid SLN-NLC formulations of curcumin were manufactured using a one-step method, without the need to disperse the nanoparticles in an additional vehicle. Modde Pro 12 was used to examine the relationship between variables and quality attributes. QbD-based formulation optimization was successfully performed using artificial neural network program (ANN), and optimum semi-solid SLN-NLC formulations were prepared. The particle size of the optimum formulations was found to be 204.7 ± 1.5 nm for SS-SLN-Opt and 198.5 ± 0.81 nm for SS-NLC-Opt, indicating that the particle sizes were within the targeted range. The amount of curcumin released from the SS-NLC-Opt formulation was 33.72 ± 4.99% at 24th Hour, which was higher than the release obtained from the eight SS-NLC formulations entered as input into the ANN program. On the other hand, while the curcumin release percentage at the 24th Hour from the SS-SLN formulations entered into the program ranged between 11.13% and 44.31%, the release amount for the SS-SLN-Opt formulation was found to be 38.34 ± 3.48%, which was within this range and close to the maximum value. Rheological characterization results indicated that the optimum semi-solid SLN and NLC formulations were more elastic than viscous. The stability of the optimum semi-solid SLN formulation at 4 °C was higher than that of the optimum semi-solid NLC after one month. In vivo studies in rats revealed that the optimum semi-solid SLN formulation exhibited higher anti-inflammatory activity than both the optimum semi-solid NLC and the conventional gel. The SS-SLN-Opt formulation effectively reduced the inflammation in rats starting from the first hour. In conclusion, the optimum semi-solid SLN formulation, which is more stable and has higher anti-inflammatory activity, is a promising alternative for the dermal delivery of curcumin.
dc.identifier.citationBadıllı, U., Şen, A., Yeğen, G., Güven Çiloğlu, B., Aksu, B., & Onay Beşikçi, A. (2025). Optimization of Semi-Solid Lipid Nanoparticle Dispersions by Quality by Design Approach for Dermal Delivery of Curcumin. Journal of Cluster Science, 36(5), 186. 10.1007/s10876-025-02915-x
dc.identifier.doi10.1007/s10876-025-02915-x
dc.identifier.issn1040-7278
dc.identifier.issn1572-8862
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105016715870
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5959
dc.identifier.volume36
dc.identifier.wosWOS:001572811000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYeğen, Gizem
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Cluster Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArtificial neural network
dc.subjectCarrageenan
dc.subjectCurcumin
dc.subjectOptimization
dc.subjectQuality by design
dc.subjectSemi-solid NLC
dc.subjectSemi-solid SLN
dc.subjectTexture profile analysis
dc.titleOptimization of Semi-Solid Lipid Nanoparticle Dispersions by Quality by Design Approach for Dermal Delivery of Curcumin
dc.typeArticle

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