The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy

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dc.contributor.authorSoykut, Ela Delikgöz
dc.contributor.authorKemal, Yasemin
dc.contributor.authorKaplan, Serkan
dc.contributor.authorKaraçin, Cengiz
dc.contributor.authorOdabaşı, Eylem
dc.contributor.authorUnal, Asude
dc.contributor.authorEr, Zehra
dc.date.accessioned2025-02-06T18:07:14Z
dc.date.available2025-02-06T18:07:14Z
dc.date.issued2023
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractAims: We aimed to examine the prognostic value of inflammatory markers such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and anemia on oncological outcomes in patients with laryngeal squamous cell carcinomas (LSCC) treated with radiotherapy. Methods: 213 LSCC patients analyzed retrospectively. Inflammatory markers were established by examining blood samples taken within 7 days before treatment. Patients were categorized into two groups: low and high according to NLR, PLR, and SII threshold values. In addition, to evaluate the effect of hemoglobin (Hb) level, the threshold value of each inflammatory marker and Hb level were combined, and 3 groups were formed (3 groups for NLR, 3 groups for PLR, and 3 groups for SII). The relationship between inflammatory markers and overall survival (OS), disease-free survival (DFS), and local regional recurrence-free survival (LRRFS) was investigated. Results: In univariate analysis, high NLR, PLR, SII, and low Hb (<13 g/dl) level were associated with worse survival (all p<0.022), except for PLR and Hb for LRRFS. OS and DFS were significantly better in patients in each group A with a low inflammatory index and high Hb (all p<0.013). In the multivariate analysis, high NLR and group CNLR (high NLR with low Hb) were statistically significant predictors of decreased OS (HR 1.85, 95% CI 1.05-3.28, p=0.033; HR 2.61, 95% CI 1.14-5.97, p=0.022) and DFS (HR 1.81, 95% CI 1.11-2.96, p=0.017; HR 3.32, 95% CI 1.20-9.16, p=0.028). Conclusion: NLR may serve as a potential prognostic biomarker in LSCC, and its predictive ability is further enhanced when NLR is combined with Hb level.en_US
dc.identifier.doi10.38053/acmj.1290362
dc.identifier.endpage236en_US
dc.identifier.issn2718-0115
dc.identifier.issue3en_US
dc.identifier.startpage227en_US
dc.identifier.trdizinid1243349
dc.identifier.urihttps://doi.org/10.38053/acmj.1290362
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1243349
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5491
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofAnatolian Current Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR-Dizin_20250206
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectAnemiaen_US
dc.subjectplatelet to lymphocyte ratioen_US
dc.subjectradiotherapyen_US
dc.subjectsystemic immune-inflammation indexen_US
dc.subjectlaryngeal squamous cell carcinomaen_US
dc.titleThe association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapyen_US
dc.typeArticleen_US

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