Successful kidney transplantation in case of completely occluded inferior vena cava and iliac veins: a case of inherited antithrombin deficiency

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dc.contributor.authorTekin, Sabri
dc.contributor.authorErok, Berrin
dc.contributor.authorWin, Nu Nu
dc.contributor.authorAgolli, Elidor
dc.contributor.authorUcak, Alper
dc.contributor.authorAkyol, Huseyin
dc.contributor.authorel Mounjali, Assiya
dc.date.accessioned2025-02-06T17:58:27Z
dc.date.available2025-02-06T17:58:27Z
dc.date.issued2021
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractProduced in the liver, Antithrombin III, now simply antithrombin (AT), is a vitamin K-independent serine protease inhibitor in the coagulation pathway. It is the most important primary physiologic inhibitor of thrombin in the human body. In addition to thrombin, AT also inhibits other coagulation serine proteases including VIIa, IXa, Xa, XIa, XIIa. (1-2) The deficiency of AT may be inherited or acquired. The incidence of inherited AT deficiency is about 1:2000-5000 in general population and is the least common of the three main anticoagulant deficiencies (the other two being protein C deficiency and protein S deficiency). (3) Its inheritance is generally in autosomal dominant fashion. The resultant procoagulant state leads to unprovoked recurrent venous thromboses and thromboembolic events such as deep vein thrombosis or pulmonary embolism which generally appear at the post-pubertal period, compared to the very low occurrence in the prepubertal period.(4) The diagnosis is based on both quantitative and qualitative measurement of AT level.(5) The measured AT activity in functional tests in healthy subjects is generally around 80% to 120%, and AT level of less than 70% is considered as being AT deficiency. This evaluation should be made while not on anticoagulation therapy, because heparin decreases AT levels for up to 10 days following its discontinuation and warfarin increases its level. (6) Patients with inherited AT deficiency rarely develops renal failure which may be caused by renal vein thrombosis or glomerular injury associated with fibrin accumulation. (7) In these young patients with end stage renal disease (ESRD), renal transplantation is currently the best therapeutic option to improve the quality of life and to avoid the risk of complications of other renal replacement treatment particularly thrombosis of the hemodialysis access. Kidney transplantation in patients with an occluded iliac veins and inferior vena cava (IVC) is a very challenging surgery to perform.(8-9) Despite the reported success in few cases for children, kidney transplant surgeries with thrombotic diseases in adults remain very limited in the literature. Herein, we present a successful kidney transplantation by using a polytetrafluoroethylene (PTFE) graft in a young male patient with AT deficiency associated with totally occluded IVC and iliac veins.en_US
dc.description.sponsorshipNingunoen_US
dc.description.sponsorshipFinanciamiento: Ninguno.en_US
dc.identifier.endpage310en_US
dc.identifier.issn0326-3428
dc.identifier.issn2346-8548
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5266
dc.identifier.volume41en_US
dc.identifier.wosWOS:000729709300013
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAsoc Regional Dialisis Trasplantes Renalesen_US
dc.relation.ispartofRevista De Nefrologia Dialisis Y Trasplanteen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectantithrombin deficiencyen_US
dc.subjectvenous thrombosisen_US
dc.subjectvascular graften_US
dc.subjectkidney transplantationen_US
dc.subjectrenal functionen_US
dc.subjectimaging evaluationen_US
dc.titleSuccessful kidney transplantation in case of completely occluded inferior vena cava and iliac veins: a case of inherited antithrombin deficiencyen_US
dc.typeArticleen_US

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