Investigation of the effectiveness of granulocyte colony-stimulating factor (G-CSF) in the treatment of atrophic rhinitis

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dc.contributor.authorPamukcu, Muhammet
dc.contributor.authorAda, Mehmet
dc.contributor.authorOzbilen, Gul
dc.date.accessioned2025-02-06T17:58:19Z
dc.date.available2025-02-06T17:58:19Z
dc.date.issued2022
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractAim: Primary acute rhinitis (AR) remains a clinical problem in developing countries. The objective of this study was to investigate the effectiveness of granulocyte colony-stimulating factor (G-CSF) administration as an alternative to current treatment methods. Material and Methods: Eighteen rabbits were divided into three groups with six rabbits in each. Group 1 consisted of the rabbits followed up without any treatment as healthy animal group. Pasteurella multocida solution was inoculated into the noses of 12 rabbits in Groups 2 and 3 with a micropipette in order to induce atrophic rhinitis. After three weeks of inoculation, rabbits in Group 1 and Group 2 were sacrificed. Group 3 was administered 5 microgram/kg G-CSF and sacrificed after four weeks. Total turbinate thickness, turbinate bone thickness, turbinate mucosal thickness, degree of cilia loss in epithelial cells, amount of submucosal gland, inflammatory cell infiltration, and changes in the turbinate bones and mucosa were examined. Results: Total turbinate thickness, turbinate bone thickness and mucosal thickness were statistically significantly lower in Group 2 compared to Group 1 (for all, p<0.01). There was a statistically significant increase in the total turbinate thickness, turbinate bone thickness and turbinate mucosa thickness of the rabbits that we treated with G-CSF (Group 3), compared to the rabbits that we created an atrophic rhinitis model and did not give treatment (Group 2) (for all, p<0.01). Discussion: We obtained findings supporting the use of G-CSF as an easy-to-apply treatment method in the medical treatment of atrophic rhinitis.en_US
dc.identifier.doi10.4328/ACAM.21102
dc.identifier.endpage702en_US
dc.identifier.issn2667-663X
dc.identifier.issue6en_US
dc.identifier.startpage698en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21102
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5167
dc.identifier.volume13en_US
dc.identifier.wosWOS:001027513600023
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectAtrophic Rhinitisen_US
dc.subjectPasteurella Multocidaen_US
dc.subjectTurbinateen_US
dc.subjectMucosaen_US
dc.subjectNasal Cavityen_US
dc.titleInvestigation of the effectiveness of granulocyte colony-stimulating factor (G-CSF) in the treatment of atrophic rhinitisen_US
dc.typeArticleen_US

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