Cytotoxic, antioxidant, iNOS, AChE. BChE inhibitory and antimicrobial activities of ethanol extract of Cyprus endemic plant Salvia veneris

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dc.contributor.authorPolatoğlu, Kağan
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorYalçın, Hüsniye Tansel
dc.contributor.authorNalbantsoy, Ayşe
dc.date.accessioned2021-05-15T12:37:35Z
dc.date.available2021-05-15T12:37:35Z
dc.date.issued2015
dc.departmentEczacılık Fakültesien_US
dc.description63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- AUG 23-27, 2015 -- Budapest, HUNGARY
dc.description.abstractSalvia veneris HEDGE. (Lamiaceae) is an endemic species of Cyprus. This species finds use as an herbal tea in the region by the misidentification instead of S. officinalis. There is no information on the biological activity of S. veneris in the literature. Here we report the biological activities of ethanol extract of this species. The cytotoxicity of the extract was evaluated against PC3, HeLa, CaCo-2, MCF-7, U87MG, HEK293, mPanc-96 cell lines. Highest activity was observed against PC3, mPanc-96 and HeLa cell lines 6.158, 8.704 and 9.907 μg/mL (IC50) respectively. The extract produced 11.00 μg/mL iNOS inhibitory activity which is higher concentration than the positive control parthenolide 0.6 μg/mL (IC50). The highest AChE and BChE enzyme inhibitory activity was observed at 10 mg/mL concentration which produced 26.54 ± 0.58 % and 35.87 ± 0.53 respectively (n = 3). Additionally the extract produced highest antimicrobial activity against C. albicans, S. epidermis, and E. faecium microorganisms with 15.6, 31.25, 31.25 μg/mL MIC values respectively. Highest DPPH scavenging activity was observed at 10 mg/mL concentration 90.83±0.0 % (n = 3) which is lower than positive control (α-tocopherol at 10 mg/mL; 92.38 ± 0.01 % (n =3)). The PRAP activity was 0.92 ± 0.04 AU at 10 mg/mL which corresponds to the activity observed for 2.1 mg/mL α-tocopherol (y = 0.2251x + 0.4354; R² = 0.9932; n = 3). The FRAP activity of the 10 mg/mL extract corresponds to activity observed for 5.70 ± 0.10 mg/mL α-tocopherol concentration (n = 3; y = 0.1268x + 0.0548; R² = 0.9922). The extract showed high potential for most of the activity tests studied. According to the presented activity results identification of the active compounds is currently under investigation.en_US
dc.identifier.endpage1458en_US
dc.identifier.issn0032-0943
dc.identifier.issn1439-0221
dc.identifier.issue16en_US
dc.identifier.startpage1458en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/558
dc.identifier.volume81en_US
dc.identifier.wosWOS:000367558100223
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthorPolatoğlu, Kağan
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofPlanta Medica
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectiNOSen_US
dc.subjectAChE.en_US
dc.subjectBChEen_US
dc.subjectSalviaen_US
dc.titleCytotoxic, antioxidant, iNOS, AChE. BChE inhibitory and antimicrobial activities of ethanol extract of Cyprus endemic plant Salvia veneris
dc.typeConference Object

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