Diagnosis and treatment methods of autoimmune myasthenia gravis : a systematic review
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Altınbaş Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Myasthenia Gravis (MG), which is an autoimmune disorder, causes abnormalities in the neuromuscular
junction and has a prevalence of 15-20 per 100,000 people. Although skeletal and extraocular muscles
are commonly affected by the disease, approximately 10% of patients have severe involvement in the
muscles necessary for respiration. A myasthenic crisis may cause life-threatening consequences. The
prevalence and incidence of autoimmune MG increase with age. Women’s disease incidence peaks
between the ages of 30 and 40, while men’s incidence peaks between the ages of 60 and 80. The
existence of autoantibodies against postsynaptic membrane proteins is the most crucial indicator of
MG. Anti-AChR (acetylcholine receptor antibody) positive is a distinct feature of MG (% 80). While antiMuSK (muscle-specific kinase antibody) positivity is detected in 1-10% of all patients, LRP4 (low density
lipoprotein receptor related protein 4) antibody positivity is seen in 3-25% of MG patients without AChR
and MuSK antibodies (anti-LRP4). Despite many methods used in the diagnosis of MG, it is not possible
to make the diagnosis in some patients because of conditions that may vary from patient to patient,
such as fluctuation in symptoms and clinical findings. Rapid diagnosis is crucial in patients with MG,
because effective treatment must begin as early as possible to prevent potentially fatal complications.
Moreover, rapid diagnosis of patients and determination of the patient’s subtype is an important step
in the treatment process. Therefore, the aim of this study is to summarize the techniques used in the
diagnosis and treatment of MG which is one of the rare diseases.
Açıklama
Anahtar Kelimeler
Myasthenia Gravis, Diagnosis Methods, Treatment Methods, Rare Diseases, Neuromuscular Disorders, Autoimmune Disorders
Kaynak
AURUM Journal of Health Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
2
Künye
Yangın, M. N., Zorlu, Y., Severcan, F. (2022). Diagnosis and treatment methods of autoimmune myasthenia gravis : a systematic review. AURUM Journal of Health Sciences, 4(2), 104-116.
