Therapeutic and prophylactic effects of fulvic acid on a breast cancer model established by MCF-7 cell line in SCID mice

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dc.authorid0000-0001-6045-0060en_US
dc.contributor.authorGülçiçek, Osman Bilgin
dc.contributor.authorOran, Duygu Sultan
dc.contributor.authorTemizyürek, Arzu
dc.contributor.authorYavuz, Erkan
dc.contributor.authorYiğitbaş, Hakan
dc.contributor.authorErçetin, Candaş
dc.contributor.authorSolmaz, Ali
dc.contributor.authorYıldırım, Funda
dc.contributor.authorSönmez, Kıvılcım
dc.contributor.authorÇelik, Atilla
dc.date.accessioned2024-07-17T11:24:18Z
dc.date.available2024-07-17T11:24:18Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Fizyoloji Ana Bilim Dalıen_US
dc.descriptionArticle Number : 5871444
dc.description.abstractIntroduction. There is still minimal scientific understanding of effects of fulvic acid (FA) on breast cancer. We investigated the prophylactic, therapeutic, and combined effects of FA in a breast cancer model created using MCF-7 cell line in severe combined immunodeficiency disease (SCID) mice. Results. Four experimental groups were established as the control group (Group C), prophylaxis group (Group P), therapeutic group (Group T), and prophylaxis + therapeutic group (Group P + T). Tumor growth was observed by the in vivo imaging system and macroscopically in mammary glands of all mice (100%) of Group C, microscopically in only one mouse of Group P (12.5%), in four mice in Group T (50%), but only one animal (12.5%) in Group P + T. Immunohistochemistry (IHC) showed that p53 staining was significantly higher in tissues of Group C compared to other groups (P < 0.05). No difference was found in IHC scores for p53 between Group P and P + T (P > 0.05). Bcl-2 staining was significantly higher in Group C compared to Group P + T (P = 0.015) and higher in Group P + T compared to Group T (P = 0.021) but no significant difference was found between Group P and others (P > 0.05). Bax staining was significantly higher in Group C compared to others (P < 0.05) but no significant difference was found between FA groups (P > 0.05). Conclusion. Prophylactic FA treatment can prevent tumor formation by inducing variations in the expression of p53, BcL-2, and Bax proteins in mammary glands of SCID mice before tumor formation. This suggests that FA may be a powerful inhibitory candidate for the prevention of tumorigenesis in breast cancer.en_US
dc.identifier.citationGülçiçek, O. B., Oran, D. S., Temizyürek, A., Yavuz, E., Yiğitbaş, H., Erçetin, C., Solmaz, A., Yıldırım, F., Sönmez, K., Çelik, A. (2024). Therapeutic and prophylactic effects of fulvic acid on a breast cancer model established by MCF-7 cell line in SCID mice. European Journal of Cancer Care, 2024. 10.1155/2024/5871444en_US
dc.identifier.issn0961-5423
dc.identifier.issn1365-2354
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4753
dc.identifier.volume2024en_US
dc.identifier.wosWOS:001252751300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthorTemizyürek, Arzu
dc.language.isoen
dc.relation.ispartofEuropean Journal of Cancer Care
dc.relation.isversionof10.1155/2024/5871444en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBCL-2 family proteinsen_US
dc.subjectApoptotic responseen_US
dc.subjectExpressionen_US
dc.subjectBaxen_US
dc.subjectMortalityen_US
dc.subjectMarkeren_US
dc.subjectIndexen_US
dc.subjectRisken_US
dc.subjectP53en_US
dc.titleTherapeutic and prophylactic effects of fulvic acid on a breast cancer model established by MCF-7 cell line in SCID mice
dc.typeArticle

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