Donors with hepatitis B surface antigen positivity: Contraindication for renal transplantation or not?

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dc.contributor.authorYavuz, Asuman
dc.contributor.authorTekin, Sabri
dc.contributor.authorYüksel, Yücel
dc.contributor.authorYücetin, Levent
dc.contributor.authorTuncer, Murat
dc.contributor.authorDemirbaş, Alper
dc.date.accessioned2021-05-15T12:37:52Z
dc.date.available2021-05-15T12:37:52Z
dc.date.issued2015
dc.departmentTıp Fakültesi, Üroloji Anabilim Dalı, Cerrahi Tıp Bilimlerien_US
dc.description52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLAND
dc.description.abstractBecause of the organ shortage, the number of patients awaiting kidney transplantation has increased rapidly requiring physicians to implement new methods to increase the number of grafts. In this study, we compared clinical and biochemical parameters of patients who received kidneys from hepatitis B surface antigen-positive (group 1) versus other living related kidney donors (group 2). The study included 414 female (15 group 1 and 399 group 2) and 816 male (20 group 1 and 796 group 2) donors for 1195 living related kidney transplantations performed between April 21, 2008 and March 1, 2011. Group 1 kidney transplantations were undertaken only if the recipient displayed a hepatitis B antibody titer >10 mIU/mL and donor hepatitis B virus (HBV) DNA was negative. Demographic characteristics, 1- and 2-year serum creatinine levels, glomerular filtration rates (GFR), and liver function test results were similar between the 2 groups. There were no new HBV infections throughout the study period. Acute rejection rates (7/35 in group 1 vs 232/1195 in group 2; P = .988), graft loss (1/35 in group 1 vs 55/1195 in group 2; P = .624), and patient loss (0/35 in group 1 vs 34/1195; P = .311) were similar between the 2 groups. Our study showed that hepatitis B surface antigen positivity was not a contraindication to living kidney donation.en_US
dc.description.sponsorshipEuropean Renal Assoc, European Dialysis & Transplant Assocen_US
dc.identifier.doi10.1093/ndt/gfv202.64
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.urihttps://doi.org/10.1093/ndt/gfv202.64
dc.identifier.urihttps://hdl.handle.net/20.500.12939/597
dc.identifier.volume30en_US
dc.identifier.wosWOS:000361215103103
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorTuncer, Murat
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantation
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDonorsen_US
dc.subjectHepatitis Ben_US
dc.titleDonors with hepatitis B surface antigen positivity: Contraindication for renal transplantation or not?
dc.typeConference Object

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