Comparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major

Basit Öğe Kaydı
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorMergen, Azize
dc.contributor.authorAksoy, Başak
dc.contributor.authorÇokluk, Mila N.
dc.contributor.authorDikme, Gürcan
dc.contributor.authorCipe, Funda
dc.contributor.authorBozkurt, Ceyhun
dc.date.accessioned2021-05-15T11:34:30Z
dc.date.available2021-05-15T11:34:30Z
dc.date.issued2019
dc.departmentTıp Fakültesi, Dahili Tıp Bilimlerien_US
dc.description45th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 24-27, 2019 -- Frankfurt, GERMANY
dc.description.abstractAllogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for beta-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) for about 70.0% of patients from 2000 onwards. The chance of finding a non-sibling fully matched family donors is higher in some ethnic groups in which consanguineous marriages are common. We have studied and compared transplant complications and outcomes in different graft types (sibling, non-sibling family and unrelated). The non-sibling matched family donor (MFD) group consisted of four mothers, three fathers, five cousins, one paternal uncle and one paternal aunt. There was no significant difference in the mean transfused CD34+ cells, engraftment, median days of neutrophil and platelet recovery were achieved (p > 0.05). The distribution of postttransplant complication did not show any significant difference between groups (p > 0.05). In univariate analysis and multivarite analyses, age, gender, Pesaro risk group (I-II vs. III) and ABO incompatibilty demonstrated a significant difference in disease free survival (p < 0.05). Furthermore, in the second step of investigating overall survival (OS), age, gender and Pesaro risk group (I-II vs. III) showed a significant difference (p < 0.05). There was no significant difference in transplant-related mortality (TRM) between groups. Non-sibling related donor transplants are important for populations where consanguineous marriages are common. Transplant groups according to graft type had similar thalassemia-free survival (TFS) and OS when using a treosulfan-based regimen in our study.en_US
dc.description.sponsorshipEuropean Soc Blood & Marrow Transplantaten_US
dc.identifier.endpage571en_US
dc.identifier.issn0268-3369
dc.identifier.issn1476-5365
dc.identifier.startpage570en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/332
dc.identifier.volume54en_US
dc.identifier.wosWOS:000487707800735
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorFışgın, Tunç
dc.institutionauthorÇokluk, Mila N.
dc.language.isoen
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofBone Marrow Transplantation
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta-Thalassemiaen_US
dc.subjectDonorsen_US
dc.subjectAllogeneic Stem Cellen_US
dc.titleComparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major
dc.typeConference Object

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu