The use and selection of design of experiments (DoE) in the development of drug product formulation

Basit Öğe Kaydı
dc.contributor.authorDemir, Önder
dc.contributor.authorAksu, Buket
dc.contributor.authorÖzsoy, Yildiz
dc.date.accessioned2025-02-06T18:01:23Z
dc.date.available2025-02-06T18:01:23Z
dc.date.issued2017
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractIn recent years, despite of the increasing use of design of experiments (DoE) in the development of drug product formulation, it has still not been sufficient. It has been known that using DoE is very useful particularly formulation of solid and semi-solid dosage forms including many components and many process parameters with unknown effect on outputs. Proper use and selection of the DoE is also important at least as using DoE in the development of drug product formulation instead of the old approaches such as trial and error. Non-correctly selected type of DoE or inappropriately applied experiments and measurements results not only wasted resources and time, but also often produces confusing or misleading data. In this review, summary information about DoE, selection of suitable type of DoE, reduction of the number of factors by using statistical screening and optimization of the drug formulations using response surface modeling (RSM) are intended to give, also briefly mentioned about the application of these methods in the development of pharmaceutical formulation. A lot of quality information (mathematical models) can be produced from the few trials conducted by means of selecting and implementation of the correct type of DoE. Thus, the development time and cost can be reduced significantly. Developed product may also have a robust process which is not sensitive to variations. © 2017, Marmara University. All rights reserved.en_US
dc.identifier.endpage222en_US
dc.identifier.issn1309-0801
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85014083746
dc.identifier.startpage211en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5379
dc.identifier.volume21en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250206
dc.subjectDesign of experimentsen_US
dc.subjectDrugen_US
dc.subjectFormulation developmenten_US
dc.subjectOptimizationen_US
dc.subjectResponse surface modelingen_US
dc.titleThe use and selection of design of experiments (DoE) in the development of drug product formulationen_US
dc.title.alternativeİlaç formülasyonu geliştirilmesinde deney tasarımı (DoE) seçimi ve kullanımıen_US
dc.typeReviewen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu