Quality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers

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dc.contributor.authorAksu, Buket
dc.contributor.authorCoşkunmeriç, Nesrin
dc.contributor.authorYeğen, Gizem
dc.contributor.authorÖzalp, Y.
dc.contributor.authorOkur, Neslihan Üstündağ
dc.date.accessioned2021-05-15T12:49:56Z
dc.date.available2021-05-15T12:49:56Z
dc.date.issued2019
dc.departmentEczacılık Fakültesien_US
dc.description.abstractBilayered oromucosal film preparations (buccal films) offer a promising way to enable drug administration via the oral cavity. Polymeric film formulations containing chitosan, sodium alginate or carbopol were evaluated to select a formulation for the development of buccal drug delivery systems. Quality by Design (QbD) is increasingly becoming an important and widely used approach in the pharmaceutical industry. QbD requires producing an understanding of the critical variables affecting the attribues of products. In this study, the principles of QbD have been uniquely applied to 54 different kinds of film formulation contain different excipients as Chitosan, Carbopol, Sodium Alginate, Glycerine, PEG 400, Propylene Glycol to obtain appropriate buccal formulations. Each of the prepared formulations contains different ingredients combination and ingredients’ ratio (% w/v), which appear changes. For this aim, to evaluate the effects of variables to the film formulations, they were characterized as thickness, weight uniformity, swelling and moisture loss. © 2019, Advanced Scientific Research. All rights reserved.en_US
dc.identifier.endpage1160en_US
dc.identifier.issn0975-2366
dc.identifier.scopus2-s2.0-85078906371
dc.identifier.scopusqualityN/A
dc.identifier.startpage1153en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/1148
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.publisherAdvanced Scientific Researchen_US
dc.relation.ispartofInternational Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBuccal Drug Deliveryen_US
dc.subjectFilmen_US
dc.subjectQuality By Designen_US
dc.titleQuality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers
dc.typeArticle

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