Altınbaş Üniversitesi Kurumsal Akademik Arşivi
DSpace@Altınbaş, Altınbaş Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Vacuum-assisted closure in secondary wound healing after pilonidal sinus surgery
(2025) Akyol, Hüseyin; Berrin, Erok
Objective: This study evaluated the utility of vacuum-assisted closure (VAC) in comparison to standard open wound care in patients operated for pilonidal sinus disease (PSD). Method: Patients with PSD who underwent standard pilonidal sinus excision-lay open technique/surgery in the Altinbas University School of Medicine Bahcelievler Medical Park Hospital, Istanbul, Turkey, between May 2015 and May 2018, were included in this study. A retrospective analysis of prospectively collected data was performed. The patients were divided into two groups according to the type of wound care, including the vacuum-assisted closure group (n=30, postoperative vacuum-assisted closure application) and the control group (n=30, standard open wound care). Wound size, postoperative infection rates and wound healing times were compared between study groups. Results: The experimental cohort included 60 patients. There was no statistically significant difference between vacuum-assisted closure and the control groups in terms of preoperative and postoperative infection rates (p>0.05). The total recovery time (time to complete wound healing) was significantly shorter in the vacuum-assisted closure group compared with the control group (21.47±4.38 days versus 67.60±7.83 days, p=0.001). Conclusion: The findings of this study emphasise that the use of vacuum-assisted closure in PSD patients treated with the lay-open technique seems notable in terms of its potential to shorten the otherwise longer secondary recovery time and thus enables the consideration of the lay-open technique once again among the most preferable methods. However, there is a need for larger scale prospective studies addressing the utility of vacuum-assisted closure in patients with PSD to validate these findings.
Dual-Functioning Metal-Organic Frameworks: Methotrexate-Loaded Gadolinium MOFs as Drug Carriers and Radiosensitizers
(2025) Karaca, Burcu; Sakarya, Deniz; Siyah, Pınar; Şenışık, Ahmet Murat; Kaptan, Yasemin; Çavuşoğlu, Ferda C.; Mansuroğlu, Demet S.; Öztürk, Sadullah; Bayazıt, Şahika S.; Barlas, Fırat
Cancer remains a critical global health challenge, necessitating advanced drug delivery systems through innovations in materials science and nanotechnology. This study evaluates gadolinium metal-organic frameworks (Gd-MOFs) as potential drug delivery systems for anticancer therapy, particularly when combined with radiotherapy. Gd-MOFs were synthesized using terephthalic acid and gadolinium (III) chloride hexahydrate and then loaded with methotrexate (MTX). Characterization via fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), magnetic resonance imaging (MRI), and X-ray diffraction (XRD) confirmed their correct structure and stability. Effective MTX loading and controlled release were demonstrated. Anticancer effects were assessed on human healthy bronchial epithelial cells (BEAS-2B) and human lung cancer cells (A549) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay under in vitro radiation therapy. MTX/Gd-MOF combined with radiotherapy showed a greater reduction in cancer cell viability (41.89% ± 2.75 for A549) compared to healthy cells (56.80% ± 1.97 for BEAS-2B), indicating selective cytotoxicity. These findings highlight the potential of Gd-MOFs not only as drug delivery vehicles but also as radiosensitizers, enhancing radiotherapy efficacy and offering promising evidence for their use in combinatory cancer therapies to improve treatment outcomes.
Combating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches
(2025) Saadat, Yalda Rahbar; Abbasi, Amin; Hejazian, Seyyed Sina; Hekmatshoar, Yalda; Ardalan, Mohammadreza; Farnood, Farahnoosh; Zahed, Sepideh Zununi
In 2008, the Society on Sarcopenia, Cachexia, and Wasting Disorders introduced a generic definition for all types of cachexia: "a complex metabolic syndrome associated with the underlying illness characterized by a loss of muscle, with or without fat loss". It is well-known that the presence of inflammatory burden in end-stage renal disease (ESRD) patients may lead to the evolution of cachexia. Since the etiology of cachexia in chronic kidney disease (CKD) is multifactorial, thus the successful treatment must involve several concomitant measures (nutritional interventions, appetite stimulants, and anti-inflammatory pharmacologic agents) to provide integrated effective therapeutic modalities to combat causative factors and alleviate the outcomes of patients. Given the high mortality rate associated with cachexia, developing new therapeutic modalities are prerequisite for ameliorating patients with CKD worldwide. The present review aims to discuss some therapeutic strategies and provide an update on advances in nutritional approaches to counteract cachexia.
Brushing motion caused no microcracks: a micro-computed tomography study
(2025) Yanık, Deniz; Özel, Şelale; Dağlı Taşman Cömert, Fügen
Objective: We evaluated the effect of brushing motion on microcrack formation in round distal canals after using multi-file rotary(MFR), single-file rotary(SFR), and single-file reciprocation(SFRc) systems via micro-computed tomography(micro-CT).
Materials and methods: Thirty-six mandibular molars were used. Samples were allocated according to files and preparation patterns (n = 12); pecking (P) and brushing (B): Group-MFR-P, Group-MFR-B, Group-SFRc-P, Group-SFRc-B, Group-SFR-P, Group-SFR-B. MFR was ProTaper Next, SFR was TruNatomy, and SFRc was WaveOne Gold. Mesial and distal were prepared using pecking motion, and additional brushing motion. Brushing motions were performed after the pecking motions with 6 strokes. Pre-and-post-instrumentation scans were obtained. Wilcoxon, Krukal-Wallis, and Mann-Whitney-U were performed.
Results: No differences were between pre-and-post-instrumentation scans (p > 0.05). Post-instrumentation microcracks were not different in Group MFR-P and Group MFR-B, Group SFRc-P and Group SFRc-B, Group SFR-P and Group SFR-B (p > 0.05).
Conclusion: The brushing motion followed by the pecking motion did not cause microcracks. None of the file systems examined in the study induced microcracks.
Chemotherapy-related cognitive impairment and kidney dysfunction
(2025) Simeoni, Mariadelina; Mulholland, Michele M.; Workeneh, Biruh T.; Capasso, Anna; Capasso, Anna; Hafez, Gaye; Liabeuf, Sophie; Malyszko, Jolanta; Mani, Laila-Yasmin; Trevisani, Francesco; De, Ananya; Wagner, Carsten A.; Massy, Ziad A.; Unwin, Robert; Capasso, Giovambattista; CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators
Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cognition, leading to a phenomenon known as chemotherapy-related cognitive impairment (CRCI). This manifests as poor attention span, disturbed short-term memory, and general mental sluggishness. This literature review explores CRCI and investigates the potential impact of KD on this phenomenon. Additionally, we highlight the shared pathogenetic mechanisms (including neurotoxicity, neuroinflammation, oxidative stress, vascular disease, electrolyte, and acid-base imbalances), clinical presentation and imaging findings between cognitive impairment in KD and CRCI. The disruption of the blood-brain barrier might be a key mechanism for increased brain permeability to anticancer drugs in nephropathic patients with cancer. Based on existing knowledge, we found a potential for heightened neurotoxicity of antineoplastic drugs and a synergistic potentiation of cognitive impairment in cancer patients with KD. However, further translational research is urgently required to validate this hypothesis.
