Phytochemical profiling, therapeutic target enzymes inhibitory, antioxidant, and cytotoxic potential of Cardopatium corymbosum

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dc.contributor.authorHasbal-Çelikok, Gözde
dc.contributor.authorÇakmak, Nermin
dc.contributor.authorÇelikok, Yasin
dc.contributor.authorDuranay, Servet
dc.contributor.authorGürdal, Bahar
dc.contributor.authorNath, Ebru Özdemir
dc.contributor.authorYılmaz-Özden, Tuğba
dc.date.accessioned2024-10-03T05:58:37Z
dc.date.available2024-10-03T05:58:37Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractCardopatium corymbosum (L.) Pers. (Asteraceae) has been used ethnomedicinally against intestinal worms, for skin diseases, and in wound treatment. This study investigated the phytochemical profile and biological activities of ethanol (CCE), methanol (CCM), and water (CCW) extracts of C. corymbosum. LC-MS/MS analysis revealed the presence of various metabolites. Antioxidant activities of the extracts were determined by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activities and ferric-reducing power (FRAP). The cytotoxicity against human breast cancer (MCF-7) and human umbilical vein endothelial (HUVEC) cell lines were determined using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. Enzyme inhibitory activities against α-amylase, α-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), thioredoxin reductase (TrxR), and elastase were measured to assess potential antidiabetic, anti-Alzheimer's, anticancer, and antiaging/wound healing effects. CCM exhibited the highest total phenolic and flavonoid contents and antioxidant activity. Fumaric acid, chlorogenic acid, vanillic acid, and rutin were identified as major components in CCM. C. corymbosum extracts, particularly those from CCE and CCM, displayed significant cytotoxicity on MCF-7 cells while exhibiting lower toxicity towards HUVEC cells. Notably, CCM demonstrated potent α-glucosidase inhibitory activity, while no α-amylase inhibition was observed. All extracts showed weak inhibition of AChE, BChE, and elastase. Conversely, the extracts displayed moderate TrxR inhibitory activity. These findings suggest that C. corymbosum possesses significant antioxidant, enzyme inhibitory, and cytotoxic potential, highlighting its promise as a source of novel bioactive molecules.en_US
dc.identifier.citationHasbal-Çelikok, G., Çakmak, N., Çelikok, Y., Duranay, S., Gürdal, B., Nath, E. Ö., Yılmaz, Özden, T. (2024). Phytochemical profiling, therapeutic target enzymes inhibitory, antioxidant, and cytotoxic potential of Cardopatium corymbosum. South African Journal of Botany, 174, 525-533. 10.1016/j.sajb.2024.09.025en_US
dc.identifier.endpage533en_US
dc.identifier.issn0254-6299
dc.identifier.scopus2-s2.0-85204635599
dc.identifier.scopusqualityQ1
dc.identifier.startpage525en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4930
dc.identifier.volume174en_US
dc.identifier.wosWOS:001324415600001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorNath, Ebru Özdemir
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.isversionof10.1016/j.sajb.2024.09.025en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectElastaseen_US
dc.subjectThioredoxin reductaseen_US
dc.subjectα-Amylaseen_US
dc.subjectα-Glucosidaseen_US
dc.titlePhytochemical profiling, therapeutic target enzymes inhibitory, antioxidant, and cytotoxic potential of Cardopatium corymbosum
dc.typeArticle

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